These researchers noticed that some patients on aromatase inhibitors
had less pain when they took high doses of vitamin D.
The effect of zoledronic acid on aromatase inhibitor
associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36 months follow-up of ZO-FAST.
Wang and Swerdloff (11) reported that the administration of testosterone with the aromatase inhibitor
testolactone prevented gonadotropin inhibition by testosterone, which suggests that a component of this inhibitory feedback mechanism is related to the conversion of testosterone to estrogen by aromatase.
For most of these patients, blocking estrogen activity with aromatase inhibitors
represents an effective treatment.
We can now be confident that to provide the best care for our patients, we should be using an aromatase inhibitor
at the earliest opportunity," commented Dr.
Another aromatase inhibitor
, the drug anastrozole, is also being tested for cancer-fighting abilities (SN: 11/24/01, p.
The most effective aromatase inhibitor
was found in white mushrooms.
Ten patients were treated with exemestane, a novel steroidal aromatase inhibitor
Men in the second group received the same testosterone doses along with an aromatase inhibitor
which markedly suppressed conversion of testosterone into estrogen.
Sonia Servaja of Hospital del Mar in Barcelona, and colleagues, assessed the association between 25-hydroxy-vitamin D (25[OH]D) concentrations and bone loss at baseline, after 3 months of supplementation, and after 1 year, in patients receiving aromatase inhibitor
therapy for early-stage breast cancer.
SAN ANTONIO--Women who were premenopausal at diagnosis of early-stage breast cancer and subsequently completed 5 years of adjuvant tamoxifen derived additional benefit from extended aromatase inhibitor
therapy, according to a new secondary analysis of a landmark clinical trial.
Arthralgias associated with aromatase inhibitor
treatment have been increasingly recognised in the last few years.