aromatase inhibitor


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aromatase inhibitor

n. Abbr. AI
Any of several drugs that affect the levels of steroids in the blood by inhibiting the enzyme aromatase. Aromatase inhibitors are used especially to lower estrogen levels to control the growth or prevent the recurrence of estrogen-sensitive tumors in post-menopausal women with breast cancer.

aromatase inhibitor

Any of a class of drugs that block the synthesis of estrogen in the body. A number of these agents have been developed to treat breast cancer, which is often a hormone-responsive malignancy.
See also: inhibitor
References in periodicals archive ?
These researchers noticed that some patients on aromatase inhibitors had less pain when they took high doses of vitamin D.
The effect of zoledronic acid on aromatase inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36 months follow-up of ZO-FAST.
Wang and Swerdloff (11) reported that the administration of testosterone with the aromatase inhibitor testolactone prevented gonadotropin inhibition by testosterone, which suggests that a component of this inhibitory feedback mechanism is related to the conversion of testosterone to estrogen by aromatase.
For most of these patients, blocking estrogen activity with aromatase inhibitors represents an effective treatment.
We can now be confident that to provide the best care for our patients, we should be using an aromatase inhibitor at the earliest opportunity," commented Dr.
Another aromatase inhibitor, the drug anastrozole, is also being tested for cancer-fighting abilities (SN: 11/24/01, p.
The most effective aromatase inhibitor was found in white mushrooms.
Ten patients were treated with exemestane, a novel steroidal aromatase inhibitor (17).
Men in the second group received the same testosterone doses along with an aromatase inhibitor which markedly suppressed conversion of testosterone into estrogen.
Sonia Servaja of Hospital del Mar in Barcelona, and colleagues, assessed the association between 25-hydroxy-vitamin D (25[OH]D) concentrations and bone loss at baseline, after 3 months of supplementation, and after 1 year, in patients receiving aromatase inhibitor therapy for early-stage breast cancer.
SAN ANTONIO--Women who were premenopausal at diagnosis of early-stage breast cancer and subsequently completed 5 years of adjuvant tamoxifen derived additional benefit from extended aromatase inhibitor therapy, according to a new secondary analysis of a landmark clinical trial.
Arthralgias associated with aromatase inhibitor treatment have been increasingly recognised in the last few years.