aromatase


Also found in: Dictionary, Acronyms, Wikipedia.

aromatase

 [ah-ro´mah-tās]
an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol.

aromatase

/aro·ma·tase/ (ah-ro´mah-tās) an enzyme activity in the endoplasmic reticulum that catalyzes the conversion of testosterone to the aromatic compound estradiol.

aromatase

(ə-rō′mə-tāz′, -tāz′)
n.
A key enzyme in the biosynthesis of steroids, especially in the conversion of androgens to estrogens.

aromatase

[ah-ro′mah-tās]
an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol.

CYP19A1

A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.

Molecular pathology
CYP19A1 mutations can up- or downregulate aromatase activity.
References in periodicals archive ?
This means that approximately two-thirds of all men do not need a natural or patented aromatase inhibitor.
Prior studies have shown that resistance to aromatase inhibitors develops due to increased activity in growth factor signaling pathways, and decreased levels of estrogen receptor-alpha (ERa).
One option is to take tamoxifen for five years followed by aromatase inhibitors for another five years giving you 10 years of protection.
A randomised trial comparing two doses of the new selective aromatase inhibitor anastrozole (Arimidex) with megestrol acetate in postmenopausal patients with advanced breast cancer.
The findings suggest that vitamin D supplementation at doses higher than the standard of 400-800 IU/day might be useful to minimize bone loss in women starting out on aromatase inhibitors and who are not eligible for bisphosphonate therapy according to current guidelines.
Researchers will monitor aromatase activity and female hormones in participants, as well as levels of conjugated linoleic acids, a group of compounds in the mushrooms that appear to be responsible for their anticancer properties.
Cancer researchers have for years been exploring the pathway by which aromatase is regulated.
The cytochrome P450 enzyme, aromatase, catalyzes the conversion of C18 estrogens to C19 androgens (Choi et al.
Stephanie Boyle, a mother-of-two from Derwent Road, Cullercoats, North Tyneside, has been getting treatment with aromatase inhibitors for the last two months.
Today the National Institute for Health and Clinical Excellence (NICE) published a positive Final Appraisal Document (FAD) on the class of breast cancer drugs known as aromatase inhibitors (AIs) post surgery.
The National Institute for Health and Clinical Excellence (Nice) has recommended the use of aromatase inhibitors, which include drugs such as femara for treating early breast cancer in postmenopausal women immediately after surgery.
Educating readers on the whole process of discovering breast cancer and guiding readers through an informed approach to the diagnosed condition possible, Dancing With Fear tactfully presents an easy-to-follow guideline of finding the tumor, dealing with the doctors and surgeries, lymphedema, chemotherapy and radiation, tamoxifen and aromatase inhibitors, fear of recurrence, complementary and alternative treatments, optimism and pessimism, support and humor, spirituality and facing death, and aftermath and reclaiming life.