aristolochic acids


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a·ris·to·loch·ic ac·ids

(ă'ris-tō-lō'kik as'idz),
Aromatic mixtures of nitrophenanthrene derivatives from plants of the genus Aristolochia. Some are components of various Chinese herbal medications, known to cause interstitial renal fibrosis that can progress to end-stage renal disease (ESRD) even after discontinuation of intake. Some are potent carcinogens, employed in animal and bacterial studies. Human urothelial carcinomas can result from their use.
References in periodicals archive ?
Among nitro-containing metabolites, the aristolochic acids are a family of substituted 10-nitro-1-phenantropic acids, biogenetically derived from benzylisoquinoline precursors, which in turn originate from tyrosine amino acid (Michl et al.
At present time a lot of derivatives of aristolochic acids have been found and their structures also reported (Michl et al.
The medicines, used for a wide range of conditions including slimming, asthma and arthritis, are derived from a botanical compound containing aristolochic acids.
With the outcome of their study, the researchers hope to raise awareness of the risks of aristolochic acids and reduce the global disease burden from this severe condition.
Aristolochic acids, a family of naturally occurring chemicals in plants grown in the United States and other countries, also were classified as known human carcinogens.
In the 12th Report on Carcinogens, released in June 2011, the National Toxicology Program adds two substances to the list of known human carcinogens: formaldehyde (formerly listed as reasonably anticipated to be a human carcinogen) and aristolochic acids (botanical chemicals found in some Aristolochia - and Asarum-based herbal remedies, which are listed for the first time).
Exposure to the aristolochic acids contained in the medicine can cause in kidney failure and cancer, particularly of the urinary tract, the MHRA said.
Exposure to aristolochic acids can cause in kidney failure and cancer, particularly of the urinary tract, the MHRA said.
A first approach to develop a sensitive method to prove the presence or absence of aristolochic acids in Chinese herbs was undertaken by Blatter and Reich (2004) and Wagner et al.
The scientists reviewed worldwide cases of aristolochic acid nephropathy (N) - a type of kidney failure caused by the intake of these acids.