aristolochic acid


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aristolochic acid

Pseudomedicine
A carcinogenic substance found in a Chinese traditional herb, Aristolochia fangchi, and in herbal weight-loss products, which has been linked to urothelial cancer and end-stage renal disease.
While the FDA issued a warning to this effect in 2001, aristolochic acid still is found in products sold in the US.

aristolochic acid

C17H11NO7, an acid derived from Aristolochia, a genus of flowering plants, and used as an herbal remedy. It is promoted as an aphrodisiac, a weight loss agent, and an anticonvulsant.
CAS # 313-67-7

CAUTION!

The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped.
See also: acid
References in periodicals archive ?
Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1/2 activation in human cells.
The paper indicates that regulatory measures that have so far been adopted by national and international agencies may be inadequate in preventing harmful exposure to aristolochic acid.
Nearer to home, an epidemic of kidney disease plus cancer affecting thousands of patients in the Danube basin was laid at the door of aristolochic acid.
It is hoped the work will identify exactly how aristolochic acid causes cells to become cancerous.
For example, aristolochic acid is not produced in the United States and the federal government has in place an import ban on it.
Dirty Dozen: 12 Supplements to Avoid Name(s) Dangers Regulatory Actions DEFINITELY HAZARDOUS: Documented organ failure or known carcinogenic properties Aristolochic acid Potent human carcinogen; FDA warning to (Aristolochia, birthwort, kidney failure, consumers and snakeroot, snakeweed, sometimes requiring industry and import sangree root, sangrel, transplant; deaths alert in April serpentary, serpentaria, reported.
They will first develop testing methods for supplements containing ephedrine-type alkaloids and aristolochic acid.
After the transplant, analysis of the herbal remedies clearly indicated the presence of aristolochic acid in 2 of the 6 Chinese herbs ingested.
The plants of the genera Aristolochia and Asarum became the interesting topic for the phytochemical and pharmaceutical researchers since the discovery of aristolochic acid derivatives.
Washington, August 8 ( ANI ): Scientists have used genome sequencing to prove that traditional Chinese herbal remedy, aristolochic acid, causes upper urinary tract cancers.
Traces of aristolochic acid, a chemical often found in Chinese herbal remedies, were also found.