argininosuccinic acid


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Related to argininosuccinic acid: Argininosuccinic aciduria

argininosuccinic acid

 [ahr″-jĭ-ne´no-suk-sin″ik]
a compound normally formed in urea formation in the liver, but not normally present in urine.

ar·gi·ni·no·suc·cin·ic ac·id

(ar'ji-ni-nō-sŭk-sin'ik as'id),
Compound formed as an intermediate in the conversion of l-citrulline to l-arginine in the urea cycle.

argininosuccinic acid

/ar·gi·ni·no·suc·cin·ic ac·id/ (ASA) (-suk-sin´ik) an amino acid formed in the urea cycle.

ar·gi·ni·no·suc·cin·ic ac·id

(ahr'ji-ni-nō-sŭk-sin'ik as'id)
Formed as an intermediate in the conversion of l-citrulline to l-arginine in the urea cycle.

argininosuccinic acid

a compound normally formed as an intermediate in urea metabolism in the liver, but not normally present in urine.
References in periodicals archive ?
HPN-100 is a pre-pro-drug of phenylacetic acid which is the active moiety of BUPHENYL(R), the only therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with the most prevalent urea cycle deficiencies including those related to carbamylphosphate synthetase, ornithine transcarbamylase and argininosuccinic acid synthetase.
A separate solution of glutamine and argininosuccinic acid (Sigma-Aldrich) in water, stored at -20[degrees]C, was also used.
HPN-100 (glycerol phenylbutyrate), an investigational product, is a pre-pro-drug of phenylacetic acid, the active moiety of BUPHENYL([R]) (sodium phenylbutyrate) Tablets and Powder, the only therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with the most prevalent urea cycle disorders: carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), and argininosuccinic acid synthetase (AS) deficiencies.