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arginase

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arginase /ar·gi·nase/ (ahr´jĭ-nās) an enzyme existing primarily in the liver, which hydrolyzes arginine to form urea and ornithine in the urea cycle.
ar·gi·nase (ärj-ns, -nz)
n.
An enzyme found primarily in the liver that catalyzes the hydrolysis of arginine to urea and ornithine.

arginase
[är′jinās]
an enzyme that catalyzes the hydrolysis of arginine during the urea cycle, producing urea and ornithine. The enzyme is found primarily in the liver but also occurs in the mammary gland, testes, and kidney.

arginase [ahr´jĭ-nās]
an enzyme of the liver that splits arginine into urea and ornithine.

arginase
an enzyme of the urea cycle in the liver that splits arginine into urea and ornithine; abbreviated ARG. Significant amounts occur only in ureotelic mammals such as dogs, cats, sheep, pigs, rats and humans. Elevated blood levels are associated with acute hepatic necrosis and determination of arginase levels in plasma or serum is a good liver-specific test in these species. Called also arginine amidinase, canavanase.


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Using a double-blind, crossover study design, scientists found that adults who consumed cocoa demonstrated decreased arginase enzymatic activity.
Other macrophage-related cytokines induced under hypoxic conditions are tumour necrosis factor (TNF)[alpha], interferon (IFN)[gamma], interleukin (IL)-10 and arginase [16,17] and the chemokines CXCL1, CCL3, CXCL8 (IL-8), and CXCL12 with its receptor CXCR4.
Further, IL-4 can inhibit NO production by upregulating arginase expression, thereby providing an alternative pathway for metabolism of L-arginine, the precursor for NO (Munder et al.
 
 
 
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