arecoline


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a·rec·o·line

(ă-rek'ō-lēn),
A colorless oily alkaloid derived from the betel nut; a cholinomimetic.

arecoline

(ă-rek′ŏ-lēn″) [ areca + -ol + -ine]
An alkaloid found in the betel nut that causes cholinergic toxicity when the nut is chewed. Arecoline also causes periodontal disease and cancer of the upper gastrointestinal tract.

arecoline

an alkaloid obtained from the nut of the tree Areca catechu. Previously, a preferred treatment for cestodes in dogs. The acetarsol, hydrobromide and carboxyphenylstilbonate salts have been used for this purpose. Oral administration causes paralysis of the worms and catharsis, so the worms are expelled alive and intact. Lower doses are used as a laxative.

arecoline challenge test
used in the diagnosis of narcolepsy in dogs; pretreatment with atropine reduces the number of cataleptic attacks with exposure to food.
References in periodicals archive ?
Effects of arecoline on adipogenesis, lipolysis, and glucose uptake of adipocytes--A possible role of betel-quid chewing in metabolic syndrome.
The triglyceride level reduces after treatment with THZ, eugenol, arecoline and vanillic acid to 42, 52, 39 and 24%, respectively (Fig.
99-fold at 25 [micro]M whereas other two phytochemicals, namely vanillic acid and arecoline, increased it by 2.
In the case of eugenol and THZ the 2DG uptake reached a maximum after 3 h of incubation, whereas in the case of metformin, arecoline and vanillic acid the maximum 2DG uptake reached a maximum in 4h (Supporting information Fig.
Eugenol and arecoline show synergistic effect with THZ and metformin on 2DG uptake
At a concentration of 25 [micro]M arecoline alone shows a maximum 2.
Isobologram for interaction of arecoline and metformin is shown in Fig.
Eugenol and arecoline upregulates expressions of GLUT4 and PI3K whereas vanillic acid does not affect significantly the expression of these genes: myotubes were treated with test compounds alone and investigated semiquantitavely for the upregulation of three different genes, namely glucose transporter 4 (GLUT4), peroxisomal proliferator-activated receptors-gamma (PPAR-[gamma]), and phosphoinositide-3-kinase (PI3K) by RT-PCR.
7) that eugenol and arecoline increases the expression of GLUT 4 transcripts by 3.
The expressions of these two genes increased when arecoline was used, whereas the expression of PI3K was elevated by eugenol.
Eugenol and arecoline have a significant effect on the GLUT 4 mediated glucose uptake in L6 myotubes which is comparable to the commercial drugs.