3 Areca nut, the main constituent of betel quid, along with betel leaves, slaked lime and tobacco, contains aromatic alkaloids such as arecoline, arecaidine
, guvacine and guvacoline.
Biochemical studies have shown that there are four alkaloids in betel nut (arecoline, arecaidine, guvacine and guvacoline) which contribute to the pathology of the disease through distinct mechanisms.
Literature has that the evidence that betel nut contain at least six related alkaloids, of which four (arecoline, arecaidine, guvacine, and guvacoline) have been conclusively identified in biochemical studies.
It has been suggested that arecaidine
is an active metabolite in fibroblast stimulation and proliferation thereby inducing collagen synthesis.
2]), arecoline hydrolyzes to arecaidine which stimulate fibroblasts and causes elevated collagen synthesis.
they increase the genetic susceptibility of OSMF patients resulting in more penetration of arecoline and arecaidine into the oral mucosa.
It contains many alkaloids such as arecoline, arecaidine
, guvacine & guvacoline, of which arecoline is the main agent.
These include arecoline, arecaidine
, guvacoline, guvacine, arecolidine, and choline (Chu, 2001; Farnsworth, 1976).
These are, arecoline, arecaidine
, guvacine, guvacoline, out of these arecoline is the main component.
Metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine
in the mouse.
5) Alkaloids present in the areca nut, assessed biochemically include arecoline, arecaidine
, guvacine and guvacoline, of which arecoline is the main agent (Flowchart 1).
The most important of these are the alkaloids-arecoline and arecaidine