arcitumomab


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arcitumomab

CEA scan Immunology A 99mTc-labelled murine IgG monoclonal Fab fragment which attaches in vivo to CEA and can be used as a tumor marker to detect GI tract CAs using immunoscintigraphy See Monoclonal antibody.
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A prospective study of 2-[18F] fluoro-2-deoxy-Dglucose/ positron emission tomography scan, 99mTc-labeled arcitumomab (CEA-scan), and blind second-look laparotomy for detecting colon cancer recurrence in patients with increasing carcinoembryonic antigen levels.
Overview: Abciximab, Arcitumomab, Basiliximab, Capromab, Cotara, Daclizumab, Edrecolomab, Igovomab, Nofetumomab, Satumomab, Sulesomab, Tositumomab and Votumumab
25,26) These have included antibodies for imaging colorectal cancer (eg, satumomab pendetide, (27) arcitumomab (24)), prostate cancer (eg, capromab pendetide (28-30)) NHL, (31) liver cancer, (32) myocardial infarcts (imciromab penlefate (33-35)), infection and inflammation (eg, sulesomab, fanolesomab (36-38)), specific infections, (2) and clots, (39) to mention a few that are now available or in development.
In 1996, Immunomedics received FDA and European regulatory approval for arcitumomab (CEA-Scan(R)), a diagnostic imaging kit comprised of a small antibody fragment against CEA that targeted a diagnostic isotope to sites of colorectal cancer.