arachidonic acid cascade

ar·a·chi·don·ic ac·id cas·cade

(ă-rak'i-don'ik as'id kas-kād'),
Eicosanoid synthetic pathway.
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Orexo also has three significant partnerships with major pharmaceutical companies for research and development programs: discovery stage collaborations with Ortho-McNeil Janssen and Janssen Pharmaceutica in respiratory inflammation and with Boehringer Ingelheim for pain, both within the arachidonic acid cascade and a clinical stage development agreement with Novartis in gastrointestinal disorders.
Nature has adapted fatty acids of vegetable sources such as n-3 and n-6 fatty acids for important cell regulatory functions through the arachidonic acid cascade [11, 12].
The inhibition of various enzymes of the arachidonic acid cascade, among these the lipoxygenases and the cyclooxygenases, might be a possible target.
The emergency response team releases cytokines that initiate the arachidonic acid cascade via eicosanoids that induce inflammation to warn of danger and initiate the healing process.
It is known in mammalian systems that cortisol is associated with modulation of the arachidonic acid cascade in the formation of prostaglandins, but it has not been studied in plants.
Metters' research focused on the arachidonic acid cascade, which resulted in the discovery of SINGULAIR[R] and TREDAPTIVE[R].
serrata and a variety of boswellic acids on the formation of products of the arachidonic acid cascade.
With the ability to model any major biological phenomena, to date it has expanded its suite of models to include adaptive immunity, the coagulation cascade and the arachidonic acid cascade.
Orexo also has three significant partnerships with major pharmaceutical companies for research and development programs: discovery stage collaborations with Ortho-McNeil Janssen and Janssen Pharmaceutica in respiratory inflammation and with Boehringer Ingelheim for inflammation and pain, both within the arachidonic acid cascade and a clinical stage development agreement with Novartis for the treatment of gastrointestinal disorders.
Metabolites of the arachidonic acid cascade in consequence activate soluble guanylatecyclase, converting GTP into c-GMP (4), which in turn causes an opening of c-GMP-dependent [Ca.
Immunetrics possesses the first known comprehensive model of the inflammatory response, which is now enhanced with key elements of the adaptive immune system, coagulation cascade and the arachidonic acid cascade.
This is to shunt over to the LO pathway of the arachidonic acid cascade.