Base Pair combines a highly customised aptamer
discovery approach with a patented multiplexing technology, bringing together DNA barcoding and next generation sequencing to enable simultaneous identification of aptamers
that bind up to 30 different targets.
The group is also adapting this system with different aptamers
so that it can sense and regulate the levels of other biomolecules in the body.
This universal process must be standardized for the selection of each target-specific aptamer
by varying the target concentration, the number of rounds, and the stringency of the binding conditions, among others.
2'-F-modified RNA aptamer
(A 10) binding to extracellular domain of PSMA was developed by protein SELEX (10).
Moreover, introducing additional functional groups increases the number of possible contacts between an aptamer
molecule and its target, which results in increased affinity and specificity of an aptamer
, even for complicated non-protein compounds, such as glycated parts of receptors of cells [4, 5].
ZE2 and its mutated aptamer
ZE2-mut, were synthesized (Sangon Biotech Co.
technology, which has been around for close to 2 decades, provides a platform for generating nucleic acid polymers capable of specific and high-affinity binding to a wide range of molecules.
It then made progress in verifying the effectiveness of its aptamer
technology by developing a biomarker for prostate cancer and an aptamer
for the West Nile virus.
market is classified by geography, application segments and aptamer
If we can use this aptamer
to target the carcinogenic protein, we might be talking about much less radical surgery in the future.
Self-assembly of supramolecular aptamer
structures for optical or electrochemical sensing.
In such assays, aptamer
pairs bind to the target protein to form a sandwich complex fixed onto a micro-plate.