aprotinin


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Related to aprotinin: Leupeptin

aprotinin

 [ap″ro-ti´nin]
an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

aprotinin

/apro·ti·nin/ (ap″ro-ti´nin) an inhibitor of proteolytic enzymes used to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft.

aprotinin

(ā-prōt′n-ĭn, ă-prōt′-)
n.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.

aprotinin

[ap′ro-ti′nin]
an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

aprotinin

A bovine polypeptide and protease inhibitor with antifibrinolytic activity that derives from basic pancreatic trypsin inhibitor (BPTI), which was added to fibrinogen in “fibrin glue”, theoretically enhancing the persistence of the fibrin clot.

It was pulled from the international market in 2007, given the concern that aprotinin increased the risk of complications and death during surgery. In 2012 the European Medicines Agency concluded that the benefits outweighed the risks, and recommended the suspension be lifted.

aprotinin

A drug used in the treatment of bleeding resulting from the excessive breakdown of the fibrin that forms blood clots. An antifibrinolytic. A brand name is Trasylol. In September 2006 the FDA issued a warning that this drug could cause renal failure, congestive heart failure, stroke and death.

aprotinin (āprō´tənin),

n a protease and kallikrein inhibitor useful in the treatment of pancreatitis.

aprotinin

a polyvalent kallikrein-trypsin inhibitor extracted from bovine mast cells; used therapeutically to inhibit fibrinolysis and in the laboratory as a preservative in plasma samples.
References in periodicals archive ?
Ghrelin measurements in serum and different plasma samples Mean (SD) percentage of baseline C-RIA 0 min 30 min EDTA- aprotinin 37[degrees]C 100.
Comparison studies between aprotinin and the lysine analogues demonstrate that aprotinin is more effective at decreasing the need for ABT but at a greater expense and risk of side effects.
The sorption of proteins such as insulin, aprotinin, [alpha]-lactalbumin, ribonuclease, myoglobin, carbonic anhydrase, peroxidase, and enolase was largely unaffected by the sorbent when the mobile phase organic solvent used was acetonitrile.
2]) added protease inhibitors (2 mM [beta]-Mercaptoethanol, 3 [micro]/mL Leupeptin 1 [micro]g/mL Aprotinin 1 [micro]/mL Pepstatin A).
Nordic Group announced today that the European Commission has approved the reinstatement of aprotinin marketing authorisations in European Union.
Princeton, NJ), aminocaproic acid (Amicar; Xanodyne Pharmaceuticals, Inc; Newport, KY), tranexamic acid (Cyklokapron; Pfizer, New York, NY), aprotinin (Trasylol; Bayer Corp, Leverkusen, Germany), and desmopressin (DDAVP; Ferring Pharmaceuticals Ltd.
After centrifugation of blood samples at 4000 rpm at room temperature for 10 min, 20-30 [micro]l/ml aprotinin (400 kallikrein inactivator units, KIU) and 1/10 volume 1 N HCl were supplemented into serum samples.
She was diagnosed with autoerythrocyte sensitization syndrome and treated with kallikrein inhibitor aprotinin at 2000 IU/kg IV in 8 h (11).
22) However, a recent observational study involving 4,374 patients undergoing CABG indicated that the use of aprotinin was associated with a doubling in the risk of renal failure requiring dialysis, a 55 percent increase in the risk of myocardial infarction or heart failure, and a 18.
High-dosage aprotinin (Trasylol) therapy--is it safe for the kidney?
After the initial evaluation the conservative approach including cardiopulmonary and hemodynamic monitorisation, pulmonary physiotherapy associated with medical treatment (analgesics, bronchodilators, aprotinin, N-acetylcysteine) was carried out.