apramycin


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apramycin

an aminoglycoside antibiotic, active against gram-negative and gram-positive bacteria. It is water soluble, easily administered in drinking water and has been used largely in treating intestinal infections in pigs and calves.
References in periodicals archive ?
Taken together, dietary supplementation of apramycin had significantly improved the growth performance and reduced pathogenic microbial load of piglets under challenged conditions.
Apramycin resistance plasmids in Escherichia coli: possible transfer to Salmonella typhimurium in calves.
High frequency transfer and horizontal spread of apramycin resistance in calf faecal Escherichia coli.
Gentamicin and apramycin were also clustered together, with a more than 50 percent degree of similarity (Cluster 2) (Figure 1).
TEM] 0 * All isolates, regardless of geographic locale, were susceptible to ceftiofur, ceftriaxone, imipenem, amikacin, apramycin, chloramphenicol, ciprofloxacin, and trimethoprim/sulfamethoxazole.
A commonly known apramycin inhibiting enzyme is apramycinacetyltransferase [AAC(3)-IV] which also inactivates gentamicin and tobramycin (7).
Isolates exhibiting apramycin resistance were observed and a representative isolate was taken for further study.
Figure 1 shows that the bacteria from chickens 5 and 6 were resistant to apramycin while the rest were sensitive.
No isolates were resistant to amikacin, apramycin, or ciprofloxacin.
For example, because it has an unusual structure, apramycin (a 4-substituted-2-deoxystreptamin) was used exclusively in animals in the hope that it would not be recognized by any of the known aminoglycoside-modifying enzymes (3).
Nucleic acid hybridization with a probe specific for 3-aminoglycoside acetyltransferase type IV: a survey of resistance to apramycin and gentamicin in animal strains of Escherichia coli.