CASP3

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CASP3

A gene on chromosome 4q34 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis, as well as various stages of embryological development. CASP3 is highly expressed in the lung, spleen, heart, liver and kidney.
References in periodicals archive ?
Caspase-3 also known as CPP32 (32 kDa cysteine protease) or apopain is a cysteine protease with aspartate specificity and a well-characterized effector of apoptosis.
The roles of Bcl-XL and apopain in the control of erythropoiesis by erythropoietin.
That apoptosis enzyme, apopain, cleaves disease-causing forms of huntingtin much more efficiently than normal forms, reports a research group headed by Michael Hayden of the University of British Columbia in Vancouver.