apomorphine


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Related to apomorphine: Apomorphine hydrochloride

apomorphine

(ăp′ə-môr′fēn′)
n.
A poisonous alkaloid, C17H17NO2, that is an analog of morphine and is used medicinally to treat Parkinson's disease and to induce vomiting.

apomorphine

an antiparkinson agent.
indications This drug is used for acute, intermittent treatment of hypomobility episodes in advanced parkinsonism.
contraindications Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects of this drug include psychosis, hallucination, depression, dizziness, headache, confusion, yawning, dyskinesias, drowsiness, somnolence, edema, syncope, tachycardia, blurred vision, rhinorrhea, sweating, vomiting, constipation, dysphagia, dry mouth, impotence, and urinary frequency. Life-threatening side effects include sleep attacks, hemolytic anemia, leukopenia, and agranulocytosis. Common side effects include agitation, orthostatic hypotension, nausea, and anorexia.

apomorphine

A morphine derivative used as an expectorant, emetic, and hypnotic. In large doses it promotes severe vomiting. Used in the treatment of Parkinson's disease. Brand names are Apo-go and Uprima.

apomorphine

an alkaloid from morphine. Used as the hydrochloride; administered parenterally it causes vomiting within 3 to 10 minutes but can also be administered orally. Stimulates receptors in the chemoreceptor trigger zone of the medulla oblongata.
References in periodicals archive ?
CTH-300 was a 12-week, randomized, double-blind, placebo controlled, parallel group, Phase 3 study examining the efficacy, safety and tolerability of apomorphine sublingual film (APL-130277) in 109 adults with levodopa-responsive Parkinson's disease complicated by OFF episodes.
The dopamine agonist apomorphine (Apo) increased swimming to a similar degree in the ziram-treated and control ZF, suggesting that the postsynaptic dopaminergic system remained intact.
Pfeiffer, "Defecatory function in Parkinson's disease: response to apomorphine," Annals of Neurology, vol.
Prescribers, nurses, patients and caregivers all need to be informed of the potential of apomorphine to address "off" episodes, as well as the specific advantages of oral delivery.
Melatonin and L-dope consistently improve certain PSG measures, but their effect on subjective sleep quality varies; valproate improves only subjective measures; apomorphine injections reduce limb movements but not awakenings (SOR: C, very small crossover and cohort trials).
Apomorphine, a short-acting dopamine agonist, can be administered subcutaneously as a bolus or infusion, intranasally or sublingually.
The recent European approval of Archimedes' innovative fentanyl pectin nasal spray product for of breakthrough cancer pain (PecFent) is one example of a product specifically designed for purpose and there are numerous other nasal drugs in clinical development at Archimedes and elsewhere, including granisetron (nausea/vomiting), diazepam and midazolam (seizures), testosterone (hypogonadism) and apomorphine (Parkinson's disease).
Dopamine agents marketed in the United States are bromocriptine (Parlodel [R]), pramipexole (Mirapex [R]), ropinirole (Requip [R], Requip XL [R]), and apomorphine (Apokyn [TM] injection) (Edmunds & Mayhew, 2009; PDE 2010a).
In each group, 45 patients were taking apomorphine at study entry; 145 total were taking it before the study.
Treating centers chose the best medical therapy, including apomorphine, for each patient as well as the specific surgical procedure (lesion or stimulation).
5 mg/ kg (ip) apomorphine hydrochloride (Sigma, USA), two wk after surgery and before cell transplantation.