apolipoprotein E deficiency
apolipoprotein E deficiencyA rare form of type-III hyperlipoproteinaemia (OMIM:107741) caused by a mutation of APOE on chromosome 19q13.32, which prevents binding of chylomicrons and VLDL to the LDL receptor.
Xanthomas (tuberous, planar, tendinous), precocious atherosclerosis and abnormal glucose tolerance.
Increased cholesterol, increased TGs, accumulation of beta-migrating remnants.
In experimental rodents, treatment with either endostatin or TNP-470 leads to dramatic reductions in the size of atherosclerotic lesions.