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apolipoprotein E

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apolipoprotein E,
a protein component of lipoprotein complexes found in very-low-density lipoprotein (VLDL), high-density lipoprotein, chylomicrons, and chylomicron remnants. It facilitates hepatic uptake of chylomicron and VLDL remnants and is elevated in patients with type III hyperlipoproteinemia. One form of apolipoprotein E has been linked to Alzheimer's disease.

apolipoprotein E
A 34-kD cholesterol-binding glycoprotein, which comprises 15% of VLDL; apoE maps to chromosome 19, is secreted by macrophages that mediate the uptake of lipoproteins–VLDL, HDL, LDL and cholesterol esters into cells via distinct binding domains for each receptor; apo-E has a central role in the metabolism of TG-rich lipoproteins, and mediates the uptake of chylomicrons and VLDL by the liver


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STOCKHOLM -- Individuals who carry the apolipoprotein E [epsilon]4 allele that increases the risk of developing Alzheimer's disease may lower their risk to that of a noncarrier through regular exercise, moderate fat intake, and low alcohol consumption, reported Tiia Ngandu at the 12th Congress of the International Psychogeriatric Association.
Also not well understood is the mechanism that underlies the link between the epsilon4 allele of the apolipoprotein E gene and Alzheimer's disease (AD).
PHILADELPHIA -- A combination of age and the presence of the apolipoprotein E [epsilon]4 allele can identify which patients with mild cognitive impairment are most likely to progress to dementia in the long term, Dr.
 
 
 
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