apolipoprotein C-III

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An 8.7 kD protein and major constituent of chylomicrons and VLDL; it is a cofactor for sphingomyelinase, an inhibitor of lipoprotein lipase, may activate lecithin; cholesterol acyltransferase and modulate uptake of TG-rich remnants by hepatic receptors; Pts with apoC-III deficiency have an ↑ risk of CAD

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