apolipoprotein C-I

ap·o·lip·o·pro·tein C-I

an apolipoprotein found in VLDL and chylomicrons. It modulates the interaction of apolipoprotein E with VLDL.

apolipoprotein C-I

a protein component of lipid that activates lecithin-cholesterol acyltransferase.


A gene on chromosome 19q13.2 that encodes a member of the apolipoprotein C1 family expressed primarily in the liver and activated when monocytes differentiate into macrophages. APOC1 is thought to modulate the interaction of APOE with beta-migrating VLDL and inhibit beta-VLDL binding to the LDL-receptor-related protein. It binds free fatty acids and reduces their intracellular esterification.