Denaturing gradient-gel electrophoresis screening of familial defective apolipoprotein B-100
in a mixed Asian cohort: two cases of [arginine.
Objective: The arginine-to-glutamine change at codon 3500 of the apolipoprotein B-100
(apo B) is a well-known genetic cause of hypercholesterolemia.
Differences in the phenotype between children with familial defective apolipoprotein B-100
and familial hypercholesterolemia.
announced today that the United States Adopted Names Council has approved the nonproprietary name mipomersen sodium for ISIS 301012, a cholesterol-lowering drug targeting apolipoprotein B-100
Of the 12 markers studied, say researchers, CRP was the best in the univariate analysis, whereas apolipoprotein B-100
and total HDL cholesterol were not as valuable.
But the real villain may turn out to beLDL's sole protein component, a molecule called apolipoprotein B-100
We used the monoclonal antibody 4E6, which is directed specifically against an epitope in the apolipoprotein B-100
(apo B-100) moiety of oxLDL that is formed from the substitution of aldehydes for lysine residues in apo B-100.
The preclinical data presented provide a mechanistic explanation for Isis' previous observations that, in mice and monkeys, treatment with antisense inhibitors of apolipoprotein B-100
(apoB) is associated with reduced liver fat content.
In addition, Isis has reaquired full ownership of ISIS 301012, its cholesterol-lowering drug targeting apolipoprotein B-100
Epidemiologic and clinical studies have consistently demonstrated that an increased plasma concentration of apolipoprotein B-100
(apo B-100),  the major protein component of LDL, is associated with an increased risk of cardiovascular disease (1).
and reacquire the intellectual property related to the GCGR and GCCR programs as well as regain full ownership of ISIS 301012, the Company's lipid-lowering drug targeting Apolipoprotein B-100
The fact that each LDL particle contains a single copy of apolipoprotein B-100
, almost fully accounting for the protein content of LDL, allows straightforward calculation of average LDL particle volume from its chemical composition (3).