apolipoprotein B-100

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ap·o·lip·o·pro·tein B-100

an apolipoprotein found in LDL, VLDL, and IDL. The ligand for the LDL receptor; absent in certain types of abetalipoproteinemia.

apolipoprotein B-100

a protein component of lipoprotein involved in the hepatic transport of lipid as very-low-density lipoprotein and low-density lipoprotein (LDL). Apoprotein B-100 links to cellulose LDL receptors. It is elevated in the plasma of patients with familial hyperlipoproteinemia.


A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.

apolipoprotein B-100

A 550 kD protein synthesized in the liver that is the major component in lipoproteins of endogenous origin–LDL, VLDL, IDL, provides the recognition signal targeting LDL to the LDL–apoB, E receptor and is considered to be the l'enfant terrible of ASHD Ref range 40 to 125 mg/dl Abnormal values ↑ in familial combined hyperlipidemia, acquired hyperlipidemia, in acute angina and MI
References in periodicals archive ?
Denaturing gradient-gel electrophoresis screening of familial defective apolipoprotein B-100 in a mixed Asian cohort: two cases of [arginine.
Objective: The arginine-to-glutamine change at codon 3500 of the apolipoprotein B-100 (apo B) is a well-known genetic cause of hypercholesterolemia.
Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia.
announced today that the United States Adopted Names Council has approved the nonproprietary name mipomersen sodium for ISIS 301012, a cholesterol-lowering drug targeting apolipoprotein B-100.
Of the 12 markers studied, say researchers, CRP was the best in the univariate analysis, whereas apolipoprotein B-100 and total HDL cholesterol were not as valuable.
But the real villain may turn out to beLDL's sole protein component, a molecule called apolipoprotein B-100 (apo-B).
We used the monoclonal antibody 4E6, which is directed specifically against an epitope in the apolipoprotein B-100 (apo B-100) moiety of oxLDL that is formed from the substitution of aldehydes for lysine residues in apo B-100.
The preclinical data presented provide a mechanistic explanation for Isis' previous observations that, in mice and monkeys, treatment with antisense inhibitors of apolipoprotein B-100 (apoB) is associated with reduced liver fat content.
In addition, Isis has reaquired full ownership of ISIS 301012, its cholesterol-lowering drug targeting apolipoprotein B-100.
Epidemiologic and clinical studies have consistently demonstrated that an increased plasma concentration of apolipoprotein B-100 (apo B-100), [5] the major protein component of LDL, is associated with an increased risk of cardiovascular disease (1).
and reacquire the intellectual property related to the GCGR and GCCR programs as well as regain full ownership of ISIS 301012, the Company's lipid-lowering drug targeting Apolipoprotein B-100.
The fact that each LDL particle contains a single copy of apolipoprotein B-100, almost fully accounting for the protein content of LDL, allows straightforward calculation of average LDL particle volume from its chemical composition (3).