APOA5

(redirected from apolipoprotein A-V)

APOA5

A gene on chromosome 11q23 that encodes apolipoprotein A-V, a minor apolipoprotein mainly associated with high-density lipoprotein (HDL), less so with VLDL and chylomicrons. It is an important determinant of plasma triglyceride (TG) levels, both stimulating TG hydrolysis by apo-CII lipoprotein lipase and inhibiting VLDL-TG production.
References in periodicals archive ?
Hyperlipidemia, and more importantly, hypertriglyceridemia in HIV patients is highly influenced by genetic variability (7) and, among the candidate genes, the newly identified apolipoprotein A-V (APOA5) [1] has emerged as probably the most potent modulator of triglyceride (TG) [2] metabolism.
Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia.
Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice.
A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration.
Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren.