The eight differentially expressed proteins included third party data (TPA): vitamin D-binding protein precursor (GC), complement C4 precursor (C4), paraoxonase 1 (PONI), A2M, endopin 1 (EN1), TPA: apolipoprotein A-IV precursor (APOA4), alpha-1-antitrypsin, and haptoglobin (HP).
Kohan AB, Wang F, Li X, et al Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function.
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has revealed that apolipoprotein A-IV
(apoA-IV) is secreted by the small intestine in response to fat absorption.
Increased apolipoprotein A-IV
in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation.
Identified proteins with expression that decreased with As exposure (higher intensity in the control gel or absent in the As-treated gel) were RAGE, glutathione-S-transferase (GST)-omega-1, contraspin (a serine--or cysteine--proteinase inhibitor isoform), apolipoprotein A-IV
, and apolipoprotein A-I.
The biological role of apolipoprotein A-IV
on chromosome segregation needs to be further investigated.
PNAS report suggests Apolipoprotein A-IV
plays important role in regulating glucose homeostasis
1]B-Glycoprotein 3-6 23 Apolipoprotein A-IV
3-6 24 Apolipoprotein C-II 2-7 25 [[beta].
Genes involved in fatty acid synthesis, such as acetyl-CoA-carboxylase and elongation of long-chain fatty acids were reduced only by PCB-77 in corn-oil--fed mice, whereas lipid transport/export genes such as fatty acid binding protein 2 and 4, ATP-binding cassette A1, and apolipoprotein A-IV
were altered in olive-oil--fed mice in response to PCBs.
(apo A-IV) is a 46-kDa plasma protein (1) with different isoforms (2).
Human Apolipoprotein A-IV
binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells.
A novel polymorphism of apolipoprotein A-IV
is the result of an asparagine to serine substitution at residue 127.