apolipoprotein A-IV

ap·o·lip·o·pro·tein A-IV

an apolipoprotein secreted with chylomicrons and also found in HDL. It participates in the catabolism of chylomicrons and VLDL. It is also required for activation of lipoprotein lipase and LCAT.


A gene on chromosome 11q23 that encodes apolipoprotein A-IV, which is a major component of high-density lipoprotein (HDL) and chylomicrons. It plays a role in chylomicrons and VLDL secretion and catabolism, and is required for efficient activation of lipoprotein lipase by ApoC-II. It is a potent activator of lecithin-cholesterol acyltransferase (LCAT).
Mentioned in ?
References in periodicals archive ?
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has revealed that apolipoprotein A-IV (apoA-IV) is secreted by the small intestine in response to fat absorption.
Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation.
Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats.
Identified proteins with expression that decreased with As exposure (higher intensity in the control gel or absent in the As-treated gel) were RAGE, glutathione-S-transferase (GST)-omega-1, contraspin (a serine--or cysteine--proteinase inhibitor isoform), apolipoprotein A-IV, and apolipoprotein A-I.
PNAS report suggests Apolipoprotein A-IV plays important role in regulating glucose homeostasis
Apofore Corporation today announced that its scientific founder at the University of Cincinnati, Patrick Tso, PhD, Professor in the Department of Pathology and Laboratory Medicine, has published new data demonstrating that the naturally occurring protein, Apolipoprotein A-IV (apoA-IV), reduces blood sugar and increases insulin secretion in mouse models of diabetes.
1]B-Glycoprotein 3-6 23 Apolipoprotein A-IV 3-6 24 Apolipoprotein C-II 2-7 25 [[beta].
Genes involved in fatty acid synthesis, such as acetyl-CoA-carboxylase and elongation of long-chain fatty acids were reduced only by PCB-77 in corn-oil--fed mice, whereas lipid transport/export genes such as fatty acid binding protein 2 and 4, ATP-binding cassette A1, and apolipoprotein A-IV were altered in olive-oil--fed mice in response to PCBs.
Apolipoprotein A-IV (apo A-IV) is a 46-kDa plasma protein (1) with different isoforms (2).
The isolation and characterization of human apolipoprotein A-IV from lipoprotein depleted serum.
Human Apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells.
A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.