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apolipoprotein A-II |
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apolipoprotein A-II, a protein component of lipoprotein complexes found in high-density lipoprotein and chlyomicrons, which activates hepatic lipase. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| To evaluate possible functional loss during the time after death until culturing of human hepatocytes, I stressed the critical need to include demonstration of apolipoprotein A-II (ApoA-II) induction in studies on the responsiveness of human hepatocytes to PPs (1). To assess apolipoprotein A-II, the UCLA group created transgenic mice that contain about 10 copies of the gene specifying this molecule and consequently produce excess apolipoprotein A-II. 5-fold increase in apolipoprotein A-II mRNA in human hepatocytes consequent to PPAR binding to the AII-PPRE. |
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