apolipoprotein A-I

ap·o·lip·o·pro·tein A-I

an apolipoprotein found in HDL and chylomicrons. It is an activator of LCAT and a ligand for the HDL receptor. A deficiency of this apolipoprotein has been associated with low HDL levels and with Tangier disease.

apolipoprotein A-I

a protein component of lipoprotein complexes found in high-density lipoprotein (HDL) and chylomicrons. It is an activator of lecithin-cholesterol acyltransferase, which forms cholesteryl esters in HDL. All apoproteins of plasma lipoproteins bind and transport lipid in the blood. A deficiency of apolipoprotein A-I is associated with low HDL levels and Tangier disease.

APOA1

A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
 
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).

apolipoprotein A-I

A 28 kD single chain protein that comprises 75% of the ApoA in HDL; apoA-I is the major protein constituent of lipoproteins, and participates in cholesterol transport by activating LCAT-lecithin:cholesterol acyltransferase; apoA-I levels are inversely proportional to the risk of CAD
References in periodicals archive ?
Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson's disease.
Apolipoprotein A-I mimetics and high-density lipoprotein function.
Also, it is pursuing TANGO, a phase III study for patients with HDL deficiency due to defects in genes coding for apolipoprotein A-I and ABCA1, within the framework of the two orphan drug designations granted by the European Medicines Agency.
The overwhelming majority of HDL contains apolipoprotein A-I (Apo A-I).
Additionally, TB increased apolipoprotein A-I concentrations and decreased apolipoprotein B concentrations.
Secondary measures included VLDL cholesterol, apolipoprotein A-I, and apolipoprotein B.
We therefore investigated the effect of testosterone on the gene expression of apolipoprotein A-I (apoA-I), hepatic lipase (HL), scavenger receptor B1 (SR-BI), and the ATP binding cassette transporter A1 (ABCA1), all of which are important regulators of HDL metabolism.
Genetic analysis of a polymorphism in the human apolipoprotein A-I gene promoter: effect on plasma HDL-cholesterol levels," J Lipid Res.
The most pertinent results in the comparison were the significant increase in apolipoprotein B, Ceruloplasmin, apolipoprotein A-I and transthyretin in the sera of patients of CMP compared to healthy subjects.
Lab tests included total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-cholesterol (non HDL-C), fasting glycemia, serum creatinine, Lp(a), apolipoprotein A-I (ApoA-I) and apolipoprotein B (ApoB) and fibrinogen.
By determining the structure of HDL, the researchers were able to conclude that the majority of physiological interactions occurring with HDL-including its twisting movements-occur at the particle surface, which is dominated by the cardioprotective protein apolipoprotein A-I.