apolipoprotein


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apolipoprotein

 [ap″o-lip″o-pro´tēn]
a nonlipid protein portion occurring in plasma lipoproteins; there are five families of apolipoproteins, grouped into four classes according to function, A, B, C, and E (the former apolipoprotein D has now been placed in class A). Apolipoproteins play a role in the transport of lipoproteins.

ap·o·lip·o·pro·tein (apo),

(ap'ō-lip'ō-prō'tēn),
The protein component of any lipoprotein complexes that is a normal constituent of plasma chylomicrons, HDL, LDL, and VLDL in humans.

apolipoprotein

/apo·lipo·pro·tein/ (ap″o-lip″o-pro´tēn) any of the protein constituents of lipoproteins, grouped by function in four classes, A, B, C, and E.

apolipoprotein

(ăp′ə-lĭp′ō-prō′tēn′, -tē-ĭn, -lī′pō-)
n.
Any of various proteins that bind to insoluble lipids to form the soluble lipoproteins, such as HDL and LDL, that transport triglycerides and cholesterol within the body.

apolipoprotein

[ap′ōlip′ōprō′tēn]
Etymology: Gk, apo + lipos, fat, protos, first
the protein component of lipoprotein complexes. Apolipoproteins bind to specific enzymes or transport specific proteins and direct lipoproteins to their sites of metabolism. See also apolipoprotein test.

apolipoprotein

Any of a family of small proteins on the surface of lipoprotein complexes, which bind to specific enzymes or transport proteins across cell membranes, which correspond to the protein moiety of lipoproteins. See HDL-cholesterol, Kringle domain.

ap·o·lip·o·pro·tein

(ap'ō-lip-ō-prō'tēn)
The protein component of lipoprotein complexes that is a normal constituent of plasma chylomicrons, high-density lipoproteins, low-density lipoproteins, and very-low-density lipoproteins in humans.

apolipoprotein

One of a number of glycoproteins forming part of the surface of LIPOPROTEIN particles in the blood. Apolipoproteins are polar structures which provide structural stability to the lipoprotein and act as receptors that help to determine the fate of the particle. Some act as cofactors for enzymes involved in lipid and lipoprotein metabolism. The level of apolipoprotein-A is genetically induced and a high level is a strong risk factor for premature coronary heart disease. It is a feature of FAMILIAL HYPERCHOLESTEROLAEMIA. Apolipoprotein-B is the binding site of low-density lipoproteins (LDL) to cellular LDL receptors and is concerned in the movement of CHYLOMICRONS from the intestine. Apolipoprotein-C is present on chylomicrons, high-density lipoproteins and very low-density lipoproteins. Apolipoprotein-E genotyping has been used to predict the likelihood of ALZHEIMER'S DISEASE.

apolipoprotein

a protein moiety occurring in plasma lipoproteins; there are five families of apolipoproteins, designated A-E.
References in periodicals archive ?
Apolipoprotein D expression in substantia nigra of Parkinson disease.
Your doctor also may order a test for apolipoprotein Al (apo Al), the chief protein in high-density lipoprotein (HDL, "good") cholesterol, and then calculate the ratio of apo B to apo Al.
Diagnosis and treatment of apolipoprotein B dyslipoproteinemias.
Apolipoprotein E is localised to the cytoplasm of human cortical neurons.
Comparison of the measurement of lipids and lipoproteins versus assay of apolipoprotein B for estimation of coronary heart disease risk: a study in familial combined hyperlipidemia.
Postprandial effects do not appear to diminish and may in fact enhance the strength of the associations between plasma lipid, lipoprotein, and apolipoprotein concentrations and risk of cardiovascular disease.
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
The clear serum was taken immediately for the analysis of glucose while lipid profile and apolipoprotein were either run immediately or run after 24 hrs.
These results show that level of apolipoprotein B, alpha-2- macroglobulin, ceruloplasmin, immunoglobulin heavy chain and 17 kDa proteins and expression of 23.
Studies have previously found an inverse relationship between high density lipoprotein cholesterol (HDL-C) or apolipoprotein A-1 levels and cardiovascular disease.
To study distribution of apolipoprotein E, B and A genes polymorphism, regulating lipid metabolism--and ID polymorphism of ACE gene in Uzbek patients with unstable angina, depending on the availability of family history of CHD.