aplastic anaemia


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Related to aplastic anaemia: megaloblastic anaemia

aplastic anaemia

Anaemia due to a failure in marrow production of RBCs, often accompanied by failure in WBC and platelet production (i.e., granulocytopaenia, thrombocytopaenia).
 
Aetiology
Toxins (benzene, toluene, insecticides), radiotherapy, drugs (carbamazepine, chemotherapy, chloramphenicol, gold salts, phenytoin, phenylbutazone, quinacrine, sulfonamides, tolbutamide), autoimmunity, SLE, post-hepatitis, pregnancy, paroxysmal nocturnal haemoglobinuria.

Prognosis
Aplastic anaemia is often unresponsive to specific therapy.

aplastic anaemia

A serious form of anaemia in which no new blood cells are formed in the bone marrow. About 30% of cases follow virus infections, especially MEASLES, MUMPS and HEPATITIS or are induced by drugs such as BUTAZOLIDINE, SULPHONAMIDES, CHLORAMPHENICOL or dipyrone. The condition results from damage to the haemopoietic stem cells often from an autoimmune process that can be checked by immunosuppressive drug treatment. Blood transfusions are often necessary to maintain life.
References in periodicals archive ?
The death rate for aplastic anaemia is 80 per cent in the first year after diagnosis without treatment.
Aplastic anaemia stops the functioning of bone marrow, disabling the production of essential blood cells.
A small number of patients with aplastic anaemia may develop leukaemia.
Angelo then went into remission for five years, only to be told the aplastic anaemia had returned in 2013.
eportedly, in the course of sightseeing, the foreign tourists spotted Aditya, a six-year-old boy being a victim of Aplastic Anaemia, a condition where bone marrow does not produce sufficient new cells to replenish blood cells.
When Liam was struck down by aplastic anaemia, a serious, rare disease caused by the bone marrow failing to produce blood cells, mum Claire, 35, had never even heard of the condition.
Last night relatives of 19-year-old Anthony Leedham, left, spoke of their heartache after he died as a result of aplastic anaemia, a rare blood disorder.
The Huyton youngster suffered from aplastic anaemia - a condition which stops the production of blood cells.
Faye, who is a pupil at St Anne's RC primary school, has aplastic anaemia which stops production of blood cells.
Mr Poulter said: "Ferrets make great pets but if a jill is not mated she can develop aplastic anaemia and die.
If that drop of blood is compatible to someone who is ill with leukaemia, aplastic anaemia and immune defences, a bone marrow transplant could save that person's life.
Two-year-old Billy suffers from Severe Aplastic Anaemia and is in need of a bone marrow and stem cell transplant.