apical membrane


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apical membrane

the microvilli-bearing portion of the epithelial cell membrane at the secretory pole.

apical membrane

the layer of plasma membrane on the apical side (the side toward the lumen) of the epithelial cells in a body tube or cavity, separated from the basolateral membrane by the zonula occludens.
References in periodicals archive ?
P-gp is expressed in a variety of normal tissues such as the apical membrane of blood-brain barrier (BBB), small intestine and kidney proximal tubule epithelial cells, protecting the body from xenobiotics and regulating drug absorption and disposition (Fenner et al.
Plasmodium falciparum apical membrane antigen 1 (AMA1) is a surface protein expressed during the asexual blood stage of P.
The active ingredient (antigen) is a membrane protein called apical membrane antigen 1, from the 3D7 strain of Plasmodium falciparum.
An extensive endocytic apparatus, located in the apical membrane of proximal tubule cells, plays a key role in the reabsorption and degradation of glomerular-filtered albumin and low-molecular-weight proteins (Marshansky et al.
Whole membrane and/or desmosomal staining were seen only in a few epithelia (transitional and stratified squamous), while in normal polarized epithelia such as gastrointestinal tract epithelium and ductal epithelium, RAAG12 expression was restricted primarily to the cytoplasm and apical membrane surface.
CFTR at these sites regulates a chloride channel in the chloride/bicarbonate exchanger located in the apical membrane and mediates the secretion of a bicarbonate-rich alkaline fluid that, in turn, maintains the solubility of secreted enzymes.
CFTR is expressed in the apical membrane of various epithelial cells and functions as a phosphorylation-regulated chloride channel and as a regulator of other ion channels (2).
In this instance, scientists studied Apical Membrane Antigen 1 (AMA1), a protein found on the cell membrane of Plasmodium falciparum, the parasite causing the most deadly malaria.
The presence of apical membrane infoldings provides increased surface area for export of proteins to form the cuticular intima of the pharynx.
To successfully study this ion channel target, we had to bring the bioassay to the target where it is most comfortable, the apical membrane of a polarized epithelium simulated in in vitro 3D culture," continued Dr.
AQP-5 appeared mainly at the apical membrane of mucous glands, basolateral membrane and basal membrane of serous acini.
The current model of absorption suggests that GLUT2 is rapidly inserted into the apical membrane in response to glucose in the intestinal lumen (Kellett and Brot-Laroche, 2005).