While SOVA can be congenital or acquired (8, 9), this patient demonstrated no known aortopathy
-associated genetic mutations in a specific limited aortopathy
panel (ACTA2, CBS, COL3A1, COL5A1, COL5A2, FBN1, FBN2, MYH11, MYLK, PLOD1, SKI, SLC2A10, SMAD3, SMAD4, TGFB2, TGFBR1, TGFBR2; aortopathy
panel performed by ARUP Laboratories, Salt Lake City, Utah) (10).
Marfan syndrome and aortopathy
, Eisenmenger's syndrome (an advanced form of pulmonary artery hypertension), peripartum cardiomyopathy with residual left ventricular dysfunction, severe aortic stenosis, and mechanical valves are all associated with high maternal and fetal death rates, and pregnancy in women with these conditions should be avoided and possibly electively terminated when it does occur, urged the experts.