A number of natural molecules such as non-polar coumarins (imperatorin and isoimperatorin), myricitrin, gossypin, quercetin, naringin, kaempferol, apigenin, hypericin, cardiospermin, chrysin, cinnamic acid, pcoumaric acid, caffeic acid, ferulic acid, sinapic acid, sanjoinine A, obovatol, magnolol, honokiol and linalool, isolated from plants have shown promising anxiolytic
activity (Fernandez et al.
Overall, the data from the study suggests that SL has some anxiolytic
and mood enhancing effects without a reduction in energy or cognition.
tests were carried out using the elevated plus-maze (EPM) model (Lister 1987; Walf and Frye 2007).
1998), and GBE usually cotains less than 5 ppm ginkgolic acids, it is too rare to contribute to anxiolytic
effects of GBE.
Research conducted by the University of Mississippi School of Pharmacy shows pterostilbene may have anxiolytic
It is suggested that differences between botanical species tested, geographical source of plants, extraction methods, dose, method and duration of administration, vehicle used, test animal species and strain, baseline anxiety levels and potential effects of the extracts on activity levels might all contribute to the divergence between these findings and those of other studies demonstrating the anxiolytic
effects of passionflower.
Concurrent use of anxiolytics
, antidepressants, mood stabilizers, sedatives, or complementary or alternative medicine remedies (e.
herb kava has been formally banned by regulatory authorities in the United Kingdom because of its potential for causing serious hepatotoxicity.
ABIO 08/01 is the first in a new class of non-addictive drugs, different from anxiolytic
sedatives, and is being developed to treat clinical anxiety states such as panic disorder or GAD.
Two valerian extracts were tested in the elevated plus maze test and the tail suspension test for anxiolytic
and antidepressive activity, respectively.
6 months of an interdisciplinary team approach reduced use of antipsychotics by 54%, reduced anxiolytic
use by 54%, reduced the use of hypnotics more than twice per week by 64%, and decreased psychiatric discharges to hospitals by 72%, Mark Coggins, Pharm.
BALTIMORE -- Chamomile extract therapy showed both anxiolytic
and antidepressive effects in a two-part randomized, controlled, blinded study of 57 patients with mild-to-moderate generalized anxiety disorder.