This study showed that SP-2a has remarkable antiviral activity against the ACV-resistant strain of HSV-1, and its potential for development as a novel antiviral agent
against other ACV-resistant viruses should be further explored.
Viral resistance has been much less of a problem with the two oral antiviral agents
approved since lamivudine.
There is an urgent need for the development of new classes of antiviral agents
such as SB 9200, that have the potential to reduce viral antigens, eliminate cccDNA, and effect viral clearance.
For them, the drugs of choice remain antiviral agents
such as AZT This drug works by blocking the action of an enzyme required by HIV to replicate, or copy, itself.
The urgency of the outbreak has led to the empiric use of broad- spectrum antibiotics and antiviral agents
in affected patients in several countries (6-12).
Eventually, physicians switched him to didanosine, another antiviral agent
Preclinical Studies of SB 9200 as an Antiviral Agent
Against HBV and HCV"
A new study suggests that HIV-infected people who have taken zidovudine for at least four months are better off switching to another antiviral agent
called didanosine, or DDI.
Food and Drug Administration for entecavir, an investigational antiviral agent
under development for the treatment of chronic Hepatitis B.
In late 1984, researchers at the Centers for Disease Control in Atlanta reported that this known antiviral agent
was effective in vitro against a virus possibly connected to AIDS (SN: 1/5/85, p.
The company's lead candidate, CMX001, is a Lipid-Antiviral-Conjugate that delivers high intracellular levels of the active antiviral agent
cidofovir-diphosphate and has broad spectrum activity against dsDNA viruses in vitro.
The expression of one such immune trigger, interferon gamma, is increased by as much as 20 times, acting as an effective antiviral agent
, but without the significant negative clinical side effects of other interferon-based therapies.