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antithyroid drug |
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antithyroid drug [-thī′roid] a preparation that inhibits the synthesis of thyroid hormones and is commonly used in the treatment of hyperthyroidism. The major antithyroid drugs are thioamide derivatives, such as propylthiouracil, and methimazole. Such substances interfere with the incorporation of iodine into the tyrosyl residues of thyroglobulin required for the production of the hormones thyroxine and triiodothyronine. They are often used to control hyperthyroidism during an anticipated remission and before a thyroidectomy. antithyroid drug Pharmacology Any of a family of therapeutic agents–eg, propylthiouracil and methimazole, containing thiourea's thiocarbamide radical, which inhibits thyroid hormone 'organification'; ADs are used to treat children,
young adults and pregnant ♀ with Graves' form of hyperthyroidism, but are not generally used for hyperfunctioning tumors or for Hashimoto's disease Adverse effects Occur in 1-5% and include rash, fever, urticaria, arthritis, transient
leukopenia, agranulocytosis–0.5%, toxic hepatitis, and aplastic anemia How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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