antithyroid drug

antithyroid drug

[-thī′roid]
a preparation that inhibits the synthesis of thyroid hormones and is commonly used in the treatment of hyperthyroidism. The major antithyroid drugs are thioamide derivatives, such as propylthiouracil, and methimazole. Such substances interfere with the incorporation of iodine into the tyrosyl residues of thyroglobulin required for the production of the hormones thyroxine and triiodothyronine. They are often used to control hyperthyroidism during an anticipated remission and before a thyroidectomy.

antithyroid drug

Pharmacology Any of a family of therapeutic agents–eg, propylthiouracil and methimazole, containing thiourea's thiocarbamide radical, which inhibits thyroid hormone 'organification'; ADs are used to treat children, young adults and pregnant ♀ with Graves' form of hyperthyroidism, but are not generally used for hyperfunctioning tumors or for Hashimoto's disease Adverse effects Occur in 1-5% and include rash, fever, urticaria, arthritis, transient leukopenia, agranulocytosis–0.5%, toxic hepatitis, and aplastic anemia
References in periodicals archive ?
Furthermore, this sensitive TBII assay may be useful for diagnosing disease remission, especially during antithyroid drug therapy.
In North America, RAI is preferred by a majority of endocrinologists, whereas antithyroid drug therapy is predominant in Europe and Japan, with surgery being employed by all for only narrow indications.
131]I fractional uptake, homogeneity of distribution, and effective half-life); and preceding antithyroid drug therapy .
Although our patient with GRTH (case 1) was asymptomatic, antithyroid drug treatment had unnecessarily been recommended just based on laboratory results.
Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay.
The evolution of the ophthalmopathy during antithyroid drug therapy and its relationship with serum thyroglobulin and antithyroglobulin antibody in patients with Basedow's disease.
Continue a low-dose antithyroid drug regimen throughout pregnancy unless there is clear evidence that the Graves' disease has remitted, he advised.
There are some common features regarding liver toxicity caused by methimazole and the other major, structurally related, antithyroid drug, propylthiouracil.
Two Graves' disease patients who spontaneously developed hypothyroidism after antithyroid drug treatment: characteristics of epitopes for thyrotropin receptor antibodies.
Propylthiouracil (PTU), an antithyroid drug, was used as a reference compound.
In hyperthyroid patients, thyroidectomy and the use of antithyroid drug, especially methimazole before definitive treatment, may decrease the risk of fractures in these patients.