SERPINC1

(redirected from antithrombin-III)

SERPINC1

A gene on chromosome 1q23-q25.1 that encodes antithrombin III, a member of the serine protease inhibitor (serpin) family that rapidly inhibits thrombin, as well as other activated serine proteases of the coagulation system, and regulates the coagulation cascade.

Molecular pathology
SERPINC1 mutations cause antithrombin-III deficiency.
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References in periodicals archive ?
Effect of calcium phosphate on thrombin and on its sensitivity to heparin and antithrombin-III.
Antithrombin-III (AT-III) is a natural occurring inhibitor of blood coagulation and plays an important part in maintaining blood in the fluid state.
Fully automated antithrombin-III assays by synthetic substrate on the Multistat III.
Hortin GL, Tollefsen DM, Santoro SAAssessment of interference by heparin co-factor II in the DuPontaca antithrombin-III assay.
2 Fibrinogen (mg/dL) (400-650) 674 668 Antithrombin-III (%) (70-120) 60 82 Fibrinogen degeneration product ([micro]g/mL) (<10) 8.
The Ventura company's Spectrolyse Antithrombin-III Assay Kit is the company's seventh product to receive FDA approval this year and expands its line of in-vitro products dedicated to assessing and diagnosing the risks of clotting and bleeding disorders.
Food and Drug Administration (FDA) 510(k) approval to market the company's new Spectrolyse(R) Antithrombin-III (anti-Xa) Assay Kit, a test system designed to assess, in a clinical setting, a patient's risk for developing blood clots, a precursor to a range of potentially life-threatening diseases.
Biopool's Spectrolyse(R) Antithrombin-III Assay Kit represents the company's seventh product to receive FDA 510(k) approval this year and expands its line of in vitro products dedicated to assessing and diagnosing the risks of clotting and bleeding disorders.
Specifically, Biopool's new assay kit measures the level of Antithrombin-III (AT-III) activity in human plasma.
While most other functional assay kits for Antithrombin-III rely on the ability of plasma to inactivate thrombin (an enzyme that facilitates clot formation), recent scientific studies have shown that the newer Biopool method is more accurate as it eliminates interference due to certain substances.