antithrombin III deficiency


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antithrombin III deficiency

Congenital antithrombin III deficiency An AD condition characterized by ↑ risk of DVT and PE. See Antithrombin III.

antithrombin III deficiency

An inherited deficiency of certain protein-splitting enzymes (proteases) which normally participate in the blood clotting cascade sequence. Women with this deficiency are at serious risk of developing THROMBOEMBOLISM in pregnancy and HEPARIN treatment is necessary.
References in periodicals archive ?
A hypercoagulable workup that included lupus anticoagulant, factor V Leiden, prothrombin G20210A mutation, homocysteine, protein C and S deficiency, and antithrombin III deficiency were negative.
When GTC won regulatory approval to sell ATryn in 2009, it was after a hearing in which New Mexico lawyer Karen Janes spoke about her hope for a treatment that could help her daughter, who inherited an antithrombin III deficiency.
Differential diagnosis of DIC included microangiopathic pathologies like infectious reasons (purpura fulminans), soft tissue injury due to trauma, snake or insect venom, severe thrombotic, thrombocytopenic purpura and hemolytic uremic syndrome and hereditary thrombotic abnormalities like antithrombin III deficiency, and heterozygous PC and PS deficiency.
The new product, which is a human antithrombin III concentrate, is indicated for the treatment of thrombosis associated with congenital antithrombin III deficiency as well as disseminated intravascular coagulation.
It's important to routinely search for these abnormalities as well as for the other leading inherited thrombophilias--factor V Leiden mutation, prothrombin gene mutations, antithrombin III deficiency, protein S deficiency and protein C deficiency--in all women with a history of venous thromboembolism who are pregnant or planning pregnancy.
7%) exhibited protein S deficiency, whereas no patient had antithrombin III deficiency.
The claims of this new patent relate to a method of treating subjects having an antithrombin III deficiency or inflammation with the administration of recombinant antithrombin III produced in the mammary gland of a non-human mammal.
This agent is indicated for patients with hereditary antithrombin III deficiency or thromboembolism and is rated pregnancy risk category B.
Inherited antithrombin III deficiency causing thrombophilia.
Antithrombin III deficiency, protein C deficiency; and protein S deficiency for example, are extremely rare in patients without a family history of venous thromboembolism.
A comparable high manifestation rate is only observed for antithrombin III deficiency, which is rare, being responsible for only ~1% of hereditary thrombophilia.