antithrombin


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Related to antithrombin: heparin, Antithrombin deficiency

antithrombin

 [an″te-throm´bin]
any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.
antithrombin I fibrin, referring to the capacity of fibrin to adsorb thrombin and thus neutralize it.
antithrombin III a naturally occurring inhibitor of blood coagulation; it is an α2-globulin member of the serpin group, synthesized in the liver and found in the plasma and various extravascular sites. It inactivates thrombin as well as certain coagulation factors and kallikrein. Inherited deficiency of the protein, an autosomal dominant disorder, is associated with recurrent deep vein thrombosis and pulmonary emboli. Complications from the disorder are prevented and, in conjunction with heparin, treated with a preparation of antithrombin III from pooled human plasma, administered intravenously.

an·ti·throm·bin

(an'tē-throm'bin),
Any substance that inhibits or prevents the effects of thrombin in such a manner that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis.

antithrombin

/an·ti·throm·bin/ (-throm´bin) any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.
antithrombin I  fibrin, referring to its capacity to adsorb thrombin and thus neutralize it.
antithrombin III  a plasma α of the serpin family that inactivates thrombin and also inhibits certain coagulation factors and kallikrein. Inherited deficiency is associated with recurrent deep vein thrombosis and pulmonary emboli; the complications are prevented and treated with a preparation of antithrombin III from pooled human plasma.

antithrombin

[-throm′bin]
a plasma serine protease inhibitor that neutralizes thrombin. Antithrombin is a major coagulation control protein.

antithrombin

A plasma protein that diminishes the activity of THROMBIN, or the amount of thrombin produced during or following coagulation of the blood.

Antithrombin

Any substance that counters the effect of thrombin, an enzyme that converts fibrinogen into fibrin, leading to blood coagulation.

antithrombin

any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.

antithrombin III (AT III)
an alpha2-globulin synthesized in the liver which is a natural inhibitor of clotting.
References in periodicals archive ?
Colorimetric assay of antithrombin III by STA analyzers [Package Insert].
Egeberg 0: Inherited antithrombin deficiency causing thrombophilia.
Indications and Usage ATryn is a recombinant antithrombin indicated for the prevention of peri-operative and peri-partum thromboembolic events in hereditary antithrombin deficient patients.
The participants were asked to handle the sample as if it was a typical clinical laboratory sample, using their routine method for the determination of antithrombin activity.
Antithrombin is the primary coagulation inhibitor as it acts with heparin to prevent the formation of thrombin.
GTC has developed goats that carry certain human genes, allowing the goats to produce human antithrombin in their milk.
Several antithrombin drugs currently under clinical development for cardiovascular indications include argatroban, efegatran, hirudin, and polyethylene glycol (PEG)-hirudin.
rEVO Biologics announced today that hereditary antithrombin (AT) deficiency, and the use of the company's lead product ATryn antithrombin (Recombinant), will be the focus of a TV segment on Behind the Mystery: Rare and Genetic Diseases, the ground breaking series on The Balancing Act[TM], America's premier morning show that airs weekday mornings on Lifetime Television.
Annualized market data for the critical healthcare market that includes markets for factor XIII concentrate, fibrinogen concentrate, antithrombin, prothrombin complex concentrate and albumin from 2002 to 2010, with forecasts to 2017.
ATryn was developed by a Massachusetts biotechnology company, GTC Biotherapeutics, by altering the genes of goats so they would produce milk rich in antithrombin, a protein that in humans acts as a natural blood thinner.
Most of the acute MI patients who consented to participate in a trial comparing antithrombin regimens did not truly understand what they were consenting to or did not make their decision autonomously said Barbara F.