antisynthetase syndrome

antisynthetase syndrome

(ant″sin′thĕ-tās″)
A syndrome identified in a subset of patients with inflammatory myopathies (dermatomyositis or polymyositis). It includes the scaling and cracking of the radial and palmar surfaces of the fingers, Raynaud phenomenon, joint inflammation, interstitial lung disease, fever, and generalized weakness.
References in periodicals archive ?
6] These include Raynaud's phenomenon, peri-ungual swelling or erythema, 'raggedy' cuticles or other features of the antisynthetase syndrome.
Antisynthetase syndrome is characterized by the presence of antihistidyl tRNA synthetase (Jo-1) antibody, interstitial lung disease (ILD), Raynaud's phenomenon, arthralgia/ arthritis and "mechanic's hands.
Recognition of "mechanic's hands," periungual erythema, abnormal capillary microscopy, and inflammatory arthritis led to new diagnoses including antisynthetase syndrome, systemic sclerosis, rheumatoid arthritis-associated interstitial lung disease, mixed connective tissue disease, dermatomyositis.