antisynthetase syndrome

antisynthetase syndrome

(ant″sin′thĕ-tās″)
A syndrome identified in a subset of patients with inflammatory myopathies (dermatomyositis or polymyositis). It includes the scaling and cracking of the radial and palmar surfaces of the fingers, Raynaud phenomenon, joint inflammation, interstitial lung disease, fever, and generalized weakness.
References in periodicals archive ?
9) We report another case of DM--ILD with negative serology for antisynthetase syndrome that was successfully managed with rituximab with no other immunosuppressive agents.
Gabay, Rituximab in the treatment of antisynthetase syndrome.
Rituximab treatment in a case of antisynthetase syndrome with severe interstitial lung disease and acute respiratory failure.
6] These include Raynaud's phenomenon, peri-ungual swelling or erythema, 'raggedy' cuticles or other features of the antisynthetase syndrome.
The anti-Jo-1 antibody test, although not sensitive, is relatively specific for interstitial lung disease and the antisynthetase syndrome mentioned above.
The antisynthetase syndrome (AS) represents a subset of connective tissue disease (CTD), usually dermatomyositis and polymyositis, in which autoantibodies to specific aminoacyl-transfer RNA synthetases develop and are associated with clinical manifestations of myositis, Raynaud phenomenon, arthritis, fever, mechanic's hands, and interstitial lung disease (ILD).
In summary, the anti-KS AS is one of the more subtle antisynthetase syndromes, with more pronounced respiratory complications and often subtle musculoskeletal manifestations.
Antisynthetase syndrome is characterized by the presence of antihistidyl tRNA synthetase (Jo-1) antibody, interstitial lung disease (ILD), Raynaud's phenomenon, arthralgia/ arthritis and "mechanic's hands.
Recognition of "mechanic's hands," periungual erythema, abnormal capillary microscopy, and inflammatory arthritis led to new diagnoses including antisynthetase syndrome, systemic sclerosis, rheumatoid arthritis-associated interstitial lung disease, mixed connective tissue disease, dermatomyositis.
Antisynthetase syndrome and malignancy: our experience.