With the introduction of semisynthetic antistaphylococcal
penicillins, the first of which was methicillin in 1959, the second wave of resistance emerged with methicillin-resistant S.
They also presented an analysis of antistaphylococcal
efficacy in a mouse peritonitis model of systemic infection, in which TXA709 was associated with enhanced (two- to four-fold greater) in vivo efficacy against both methicillin-sensitive S.
Considering the low EGCG toxicity and low effective in vitro concentrations together with supportive data on its transdermal absorption and accumulation in body tissues, we suggest EGCG as a promising compound for the development of new antistaphylococcal
formulations, especially for the treatment of minor staphylococcal skin and skin structure infections.
2) Isolates are often resistant to cephalosporins, penicillin, ampicillin, and antistaphylococcal
penicillins, and they are universally resistant to vancomycin and rifampin.
activity of ceftobiprole, a new broad-spectrum cephalosporin.
Howden BP, Grayson ML: Dumb and dumber--the potential waste of a useful antistaphylococcal
agent: emerging fusidic acid resistance in Staphylococcus aureus.
Typically, antimicrobial agents include antistaphylococcal
penicillins or the cephalosporins.
and cytotoxic compounds from Hyptis pectinata.
aureus is identified and the patient will respond to an antiseptic shampoo and a five-day course of an appropriate antistaphylococcal
Presently, there is a need for reconsideration of empiric antistaphylococcal
antibiotic selection for seriously ill patients with suspected community-associated S.
She completed 18 months of INH/ethambutol and a lengthy course of antistaphylococcal
Cubicin (6 mg/kg IV once daily) was as effective as the standard of care: combination intravenous therapy with antistaphylococcal
semisynthetic penicillin (2 g every 4 hours) or vancomycin (1 g every 12 hours), both with initial low-dose gentamicin.