antisense compound


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.
Related to antisense compound: Antisense therapy, antisense DNA

antisense compound

Any of the manufactured compounds that may alter disease processes by blocking the production of harmful proteins by diseased cells. These molecules seek out and impede the functioning of a diseased cell's messenger RNA (a “sense” strand). Without this intervention, the RNA would carry basic directions for the production of disease-causing proteins. Synonym: antisense drug
See also: compound
References in periodicals archive ?
This article is another important milestone in providing strong evidence of the antisense mechanism of action as well as in demonstrating that antisense compounds work in a variety of ways to inhibit protein production," said Stanley Crooke, M.
In some cases, the antisense compound kept the virus at bay for as long as 26 weeks.
Chirally pure forms of these drugs may have the potential of increased biological activity compared to first generation antisense compounds.
The purpose of this study, and studies to be reported in later papers, was to better understand the value of various chemical modifications of antisense compounds by comparing the effects of these modifications in animals on the pharmacokinetic, pharmacological and toxicological properties of the compounds.
Since its inception, Isis has invested considerable resources in medicinal chemistry with the goal of creating new generations of antisense compounds that will enable Isis to create safer and more effective drugs.
Most antisense compounds currently in development incorporate "first generation" chemistry and replace the phosphodiester linkage with another form of phosphate linkage which is much less susceptible to degradation.
The specificity of antisense compounds holds great promise for therapeutic advances in this area.
Stepkowski added, "Isis' ICAM-1 antisense compound is well tolerated by mice at the doses which result in transplant survival.
The second-generation antisense compound is more potent and specific than the first generation molecules described last fall.
It is designed to potentially enhance the pharmacokinetics and viral and clinical response to treatment with AVI's proprietary NEUGENE(R) antisense compound, AVI-4065, in patients with HCV.
Like a key in a lock, NEUGENE antisense compounds are designed to match up perfectly with a specific gene or viral sequence, blocking the function of the target gene or virus.
Like a key in a lock, NEUGENE antisense compounds are designed to match up precisely with a specific gene or viral sequence, blocking its function.