antisense


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Related to antisense: Antisense strand, Antisense drugs

strand

 [strand]
a thread or fiber or a structure resembling one.
antisense strand the strand of a double-stranded nucleic acid that is complementary to the sense strand; in DNA it is the template strand on which the mRNA is synthesized.
sense strand the strand of a double-stranded nucleic acid that encodes the product; in DNA it is the strand that encodes the RNA, having thus the same base sequence except changing T for U in the RNA. See also antisense strand.

an·ti·sense DNA

the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene.

antisense

/an·ti·sense/ (an´te-) (an´ti-sens) referring to the strand of a double-stranded molecule that does not directly encode the product (the sense strand ) but is complementary to it.
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Antisense strand of DNA, complementary to the sense (coding) strand and serving as a template for RNA synthesis.

antisense

(ăn′tē-sĕns′, ăn′tī-)
adj.
Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

antisense

[an′tēsens]
pertaining to a ribonucleic acid (RNA) molecule that is complementary to the messenger RNA (mRNA) produced by transcription of a given gene. Antisense RNA synthesized in the laboratory hybridizes with the complementary mRNA molecules, thereby blocking the synthesis of specific proteins. Compare sense.

gene therapy

Molecular medicine Treatment of disease by replacing, altering or supplementing the genetic structure of either germline–reproductive or somatic–nonreproductive cells a structure that is absent or abnormal and responsible for disease; any of a group of techniques in molecular biology, in which a gene of interest is manipulated, either by mutational inactivation–eg, the 'knock-out mouse', or by replacement, if it causes a particular disease; GT encompasses any therapy that specifically targets the core defect in inherited diseases, either by affecting somatic cells or germ line cells which are usually inserted into the host's genome; strategies for GT include
1. Introduction of a recombinant retrovirus with the missing gene, the promoter, and the gene regulator sequence in the 'package', and.
2. Implantation of the colonies of cells producing the missing factor(s)–eg, α1-antitrypsin deficiency with the missing enzyme introduced into 'carrier' fibroblasts
Gene therapy strategies
Antibody genes Interfere with cancer-related protein activity in tumor cells
Antisense Block synthesis of proteins encoded by a defective gene in the host
Chemoprotection Add proteins to cells that protect them from the toxic effect of chemotherapy
Immunotherapy Enhance host defense against cancer
Oncogene downregulation Turn off genes involved in uncontrolled growth and metastases of tumor cells
Suicide gene/pro-drug therapy Insert proteins that metabolize normal drugs and ↑ their toxicity to proliferating–ie tumor cells
Tumor suppressor genes Replace defective/deficient cancer-inhibiting genes
.

an·ti·sense

(an'tē-sens)
Pertaining to the strand of a double-stranded DNA or RNA molecule that is complementary to the sense strand.
References in periodicals archive ?
The company has successfully commercialized the world's first antisense drug and has 11 antisense drugs in development to treat metabolic, cardiovascular and inflammatory diseases, and cancer.
Antisense Therapeutics is currently undertaking a Phase I clinical trial of ATL1102 for Multiple Sclerosis.
Although researchers have been conducting laboratory and animal tests of antisense compounds for about a decade, clinical data are just starting to roll in at scientific meetings.
AVI's proprietary antisense chemistry has pharmaceutically important properties that are complementary to our existing technology," said Larry J.
Mark Diamond, CEO of Antisense commented: "Although a drug's efficacy is typically not established until completion of Phase II clinical trials, this "proof of concept" study serves as a relatively inexpensive and efficient method of indicating the activity of ATL1101, while providing valuable data.
The researchers hope that the antisense molecules will kill any leukemia cells that stow away in the transplant material, says Bishop.
AVI also has three ongoing Cooperative Research and Development Agreements (CRADAs) with various government agencies underway to test its antisense drugs against a variety of infectious viruses:
Canada's affirmation of Enzo's rights to our pioneering work in genetic antisense will allow us to move forward with this technology's promising applications, such as the Enzo-sponsored HIV clinical trial now underway in the U.
Key study results show the potential significance of antisense inhibitors of ICAM-1 in organ transplant survival:
At the University of Nebraska Medical Center in Omaha, Eliel Bayever and his colleagues have conducted a preliminary evaluation of one type of antisense in 11 people suffering from either an acute or premalignant form of myelogenous leukemia.
We believe the presence and persistence of each of the three NEUGENE drugs in the CSF after a single administration suggest potentially unique therapeutic applications for this class of antisense drugs," said Dr.
Using a technique called antisense genetics, Calgene researchers permanently endowed their tomato with a backward (antisense) copy of the gene for polygalacturonase (PG), a fruit-softening enzyme.