antipsychotic drug


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Related to antipsychotic drug: schizophrenia, antidepressant drug

antipsychotic drug

n.
Any of a group of drugs, such as the phenothiazines or butyrophenones, that are used to treat psychosis. Also called major tranquilizer.

antipsychotic

adjective Referring to an antipsychotic drug.

noun Any drug that attenuates psychotic episodes.
 
Agents
Phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, diphenylbutylpiperidines.
 
Main types of antipsychotics
Typical and atypical, which differ in their side/adverse effects.
 
Indications
Management of schizophrenic, paranoid, schizo-affective and other psychotic disorders; acute delirium, dementia, manic episodes (during induction of lithium therapy), control of movement disorders (in Huntington’s disease), Tourette syndrome, ballismus, intractable hiccups, severe nausea and vomiting (by blocking the medulla’s chemoreceptor trigger zone).
 
Adverse effects
Extrapyramidal effects (dystonia, akathisia, parkinsonism), tardive dyskinesia due to blocking of basal ganglia; sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion and constipation) are due to blocking of histaminic, cholinergic and adrenergic receptors.
References in periodicals archive ?
In WE-D, which is considered as a subtype of TD, abnormal movements in the neck, face, mouth, arms, and legs appear shortly after a rapid reduction of the antipsychotic drug dose or sudden discontinuation of the drug in a portion of patients who do not display abnormal involuntary movements during antipsychotic treatment.
Findings from another study using Medicaid data found that children in areas underserved by child psychiatrists are likelier to be prescribed atypical antipsychotic drugs for nonpsychotic conditions than in areas where more child psychiatrists practice.
PHILADELPHIA - Long-acting, injectable formulations of antipsychotic drugs significantly boosted treatment compliance in patients with schizophrenia in a review of reimbursement records for more than 3,600 patients.
Now, a new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) reveals how antipsychotic drugs interfere with normal metabolism by activating a protein called SMAD3, an important part of the transforming growth factor beta (TGFbeta) pathway.
Obecure is focused on development of Histalean([R]) (high dose betahistine) as adjunctive to antipsychotic drug therapy for improved treatment of schizophrenia, bipolar disorder and major depression.
The mechanism of this effect appears to be multifactorial, with antipsychotic drugs causing weight gain and insulin resistance that triggers hyperprolactinemia; the drugs also cause the pituitary to produce elevated levels of luteinizing hormone, Dr.
Snowden pointed out that one excess death is not a trivial number, "when presented with this data, I have yet to have a nursing home family say that they don't want an antipsychotic drug given to their relative.
Antipsychotic drugs are used in up to 45 per cent of nursing homes to help with agitation, a common and distressing symptom of dementia.
5% of subjects reported that they were simultaneously treated with more than one antipsychotic drug, an unapproved treatment for schizophrenia.
In its regulatory language, the CMS said nursing home residents who have not used antipsychotic drugs should not receive them "unless antipsychotic drug therapy is necessary to treat a specific condition as diagnosed and documented in the clinical record.
New York) asked the FDA for permission to sell its antipsychotic drug Abilify to treat schizophrenia in adolescents.