antipsychotic drug


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Related to antipsychotic drug: schizophrenia, antidepressant drug

antipsychotic drug

n.
Any of a group of drugs, such as the phenothiazines or butyrophenones, that are used to treat psychosis. Also called major tranquilizer.

antipsychotic

adjective Referring to an antipsychotic drug.

noun Any drug that attenuates psychotic episodes.
 
Agents
Phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, diphenylbutylpiperidines.
 
Main types of antipsychotics
Typical and atypical, which differ in their side/adverse effects.
 
Indications
Management of schizophrenic, paranoid, schizo-affective and other psychotic disorders; acute delirium, dementia, manic episodes (during induction of lithium therapy), control of movement disorders (in Huntington’s disease), Tourette syndrome, ballismus, intractable hiccups, severe nausea and vomiting (by blocking the medulla’s chemoreceptor trigger zone).
 
Adverse effects
Extrapyramidal effects (dystonia, akathisia, parkinsonism), tardive dyskinesia due to blocking of basal ganglia; sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion and constipation) are due to blocking of histaminic, cholinergic and adrenergic receptors.
References in periodicals archive ?
Aripiprazole is a new generation of antipsychotic drugs developed by Otsuka Pharmaceutical Co.
Residents without a history of antipsychotic drug use should not receive these drugs unless necessary to treat a specific condition as diagnosed and documented in the clinical record.
Antipsychotic drugs are classed as typical, or first generation, and atypical (second generation).
They found that an enzyme called HDAC2 was highly expressed in the brain of mice chronically treated with antipsychotic drugs, resulting in lower expression of the receptor called mGlu2, and a recurrence of psychotic symptoms.
The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: A review and metaanalysis.
The risk of developing TD and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase.
Use of a second-generation antipsychotic drug was associated with a 3.
The study, published in the British Medical Journal, found patients treated with haloperidol were twice as likely to die compared with those taking antipsychotic drug risperidone (resperdal).
Antipsychotic drugs are used in up to 45% of nursing homes to help with agitation, a common symptom of dementia.
We are delighted that the results of this clinical study suggest that the adjunctive use of ACP-103 has the ability to reduce the side effects associated with antipsychotic drug treatment," said Mark R.
Second-generation atypical versus first-generation conventional antipsychotic drug treatment in schizophrenia: Another triumph of hope over experience?
The analysis focused on patients who began treatment with either an oral or a longacting injected formulation of an antipsychotic drug, and who had at least 12 months of continuous health coverage prior to the index prescription, according to Dr.