antipsychotic


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Related to antipsychotic: Antipsychotic drugs, Atypical antipsychotic

antipsychotic

 [an″te-, an″ti-si-kot´ik]
modifying psychotic behavior.
antipsychotic agent any drug that favorably modifies psychotic symptoms; categories include the phenothiazines, butyrophenones, thioxanthenes, dibenzodiazepines, diphenylbutylpiperidines, dihydroindolones, and dibenzoxazepines. They are chemically diverse but pharmacologically similar. Formerly called major tranquilizer.

Antipsychotics stabilize mood and reduce anxiety, tension, and hyperactivity. They are also effective in helping to control agitation and aggressiveness. Delusions and hallucinations are often modified and may be eliminated by such an agent, but once the drug is discontinued, the delusions and hallucinations often return within a short while. Different antipsychotic agents bind to dopamine, histamine, muscarinic, cholinergic, α-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is thought to be responsible for the major antipsychotic, antiemetic effects of these agents as well as neurologic side effects. The drugs are contraindicated in patients suffering from central nervous system depression, severe allergy, Parkinson's disease, or a blood dyscrasia. There also is the possibility of drug-drug interaction when neuroleptic drugs are given concurrently with barbiturates, alcohol, tricyclic antidepressants, antihypertensives, meperidine, anticonvulsants, or levodopa.

Many antipsychotics have alarming side effects (see extrapyramidal effects); thus there must be thorough patient education and individualized adjustments in dosage. The side effects can usually be minimized by gradually increasing the dosage until the optimum for the individual is reached. Side effects such as a discomforting restlessness and agitation (akathisia), involuntary rhythmic movements of the trunk and limbs, parkinsonism, and tardive dyskinesia are often misinterpreted as symptoms of some unrelated disorder; these are often the reason for noncompliance or stopping of medication by patients. Approximately 20 per cent of the patients treated with neuroleptics for long periods develop tardive dyskinesia, a syndrome of choreoathetoid movements of the tongue, mouth, face, neck, limbs, and trunk, which may continue after the drug is stopped.

Antipsychotic agents are sometimes prescribed for conditions other than mental disorders. They can be beneficial in the control of nausea, in the treatment of intractable hiccups, in controlling the movement disorders associated with Huntington's chorea and Gilles de la Tourette's syndrome, and, in combination with other drugs, for the control of pain.

an·ti·psy·chot·ic

(an'tē-sī-kot'ik),
1. Synonym(s): antipsychotic agent
2. Denoting the actions of such an agent (for example, chlorpromazine).

antipsychotic

/an·ti·psy·chot·ic/ (-si-kot´ik) effective in the treatment of psychotic disorders; also, an agent that so acts. Antipsychotics are a chemically diverse but pharmacologically similar class of drugs; besides psychotic disorders, some are also used to treat movement disorders, intractable hiccups, or severe nausea and vomiting.

antipsychotic

(ăn′tē-sī-kŏt′ĭk, ăn′tī-)
adj.
Counteracting or diminishing the symptoms of psychotic disorders, such as schizophrenia.
n.
An antipsychotic drug.

antipsychotic

[-sīkot′ik]
Etymology: Gk, anti + psyche, mind, osis, condition
1 pertaining to a substance or procedure that counteracts or diminishes symptoms of a psychosis.
2 an antipsychotic drug. Categories include the phenothiazine derivatives, butyrophenones, thioxanthene derivatives, dibenzodiazepines, diphenylbutylpiperidines, dihydroindolones, and dibenzoxazepines. They are chemically diverse but pharmacologically similar. Formerly called major tranquilizer.

antipsychotic

adjective Referring to an antipsychotic drug.

noun Any drug that attenuates psychotic episodes.
 
Agents
Phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, diphenylbutylpiperidines.
 
Main types of antipsychotics
Typical and atypical, which differ in their side/adverse effects.
 
Indications
Management of schizophrenic, paranoid, schizo-affective and other psychotic disorders; acute delirium, dementia, manic episodes (during induction of lithium therapy), control of movement disorders (in Huntington’s disease), Tourette syndrome, ballismus, intractable hiccups, severe nausea and vomiting (by blocking the medulla’s chemoreceptor trigger zone).
 
Adverse effects
Extrapyramidal effects (dystonia, akathisia, parkinsonism), tardive dyskinesia due to blocking of basal ganglia; sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion and constipation) are due to blocking of histaminic, cholinergic and adrenergic receptors.

an·ti·psy·chot·ic

(an'tē-sī-kot'ik)
1. Synonym(s): antipsychotic agent.
2. Denoting the actions of such an agent.

antipsychotic

A drug used in the treatment or control of severe mental illness such as SCHIZOPHRENIA. The antipsychotic drugs include such groups as the benzamides (Amisulpride, Dolmatil, Solian); benzisoxzoles (Risperidal); butyrophenones (Anquil, Dozic, Droleptan, Haldol, Serenace); phenothiazines (Fentazin, Largactil, Melleril, Modecate, Moditen, Neulactil, Nozinan, Stelazine); and thioxanthines (Clopixol, Depixol).

an·ti·psy·chot·ic

(an'tē-sī-kot'ik)
1. Synonym(s): antipsychotic agent.
2. Denoting the actions of such an agent (e.g., chlorpromazine).

antipsychotic

effective in the management of manifestations of psychotic disorders; also, an agent that so acts. There are several classes of antipsychotic drugs (phenothiazines, thioxanthenes, dibenzazepines and butyrophenones), all of which may act by the same mechanism, i.e. blockade of dopaminergic receptors in the central nervous system. Called also neuroleptic and major tranquilizer.
References in periodicals archive ?
Because BPSD are one of the main reasons people with dementia are placed in nursing homes, it is not surprising that rates of antipsychotic use are higher in these settings than in the community.
At the other end of the spectrum is the prolactin-sparing antipsychotic aripiprazole, which is associated with sexual dysfunction in about 5% of treated patients.
Thorne's (2008) Interpretive Description qualitative methodology was used to explore relatives' understanding of the use of antipsychotic medication for managing BPSD in their relative with dementia in the RAC setting.
Conclusion: Because of the widespread use of atypical antipsychotics, we observed atypical antipsychotic exposures more than typical antipsychotic exposures.
Adverse effects of antipsychotics, such as insomnia, dry mouth, drowsiness, and blurred vision, are expected to affect the growth by decreasing the level of acceptance in patients.
Antipsychotics were originally developed for patients with schizophrenia or psychosis.
Another related problem is the use of high or 'super high' dosages of antipsychotic medication, a situation that is common when more than one antipsychotic medication is being administered.
Psychiatrists were invited to answer a multiple-choice questionnaire whereby they ranked, for each patient under their care, their current clinical condition, their adherence to antipsychotic treatment and their current antipsychotic treatment, using the following instruments:
NHC did not initially include antipsychotic use as a measure of quality.
In the pooled sample, comparisons between the antipsychotic and nonantipsychotic groups with respect to demographic and clinical variables were conducted with Chi-square tests, independent-samples t -test or Mann-Whitney U -test, as appropriate.
Sixty-six percent of the antipsychotic prescriptions for Medicare Part D patients were prescribed by internists and family medicine physicians, and 16% were written by psychiatrists or neurologists, the report said.
sup][1],[2] Drug-induced stroke adverse events are, accordingly, of great public concern, including a potential cerebrovascular risk from antipsychotic use.