antiprogestin

antiprogestin

 [an″te-, an″ti-pro-jes´tin]
a substance that inhibits the formation of progestational agents; the most common example is mifepristone.

an·ti·pro·ges·tin

(an'tē-prō-jes'tin),
A substance that inhibits progesterone formation, that interferes with its carriage or stability in the blood, or that reduces its uptake by, or effects on, target organs (for example, RU486, mifepristone).

antiprogestin

/anti·pro·ges·tin/ (an″te-) (an″ti-pro-jes´tin) a substance that inhibits the formation, transport, or action of progestational agents.

antiprogestin

[-prōjes′tin]
a substance that interferes with the production, uptake, or effects of progesterone. The most common example is mifepristone.

an·ti·pro·ges·tin

(an'tē-prō-jes'tin)
A substance that inhibits progesterone formation, interferes with its carriage or stability in the blood, or reduces its uptake by, or effects on, target organs (e.g., RU-486, mifepristone).
Synonym(s): progesterone antagonist.
References in periodicals archive ?
The Antiprogestin RU 486 in Advanced Breast Cancer: Preliminary Clinical Trial," Bulletin of Cancer, 74:455, 1987.
The paper showed induction of high levels of gene expression in the muscle and secretion of protein in bloodstream after administration of very low doses of an antiprogestin drug.
Predictors Of Failed Attempted Abortion With The Antiprogestin Mifepristone (RU 486), 162 Am.
The development of the antiprogestin drug mifepristone (RU 486) has been perhaps the greatest breakthrough in fertility control technology since the discovery of oral contraceptives.
The findings were reported in a poster entitled "Characterization of progesterone receptor biomarker for predicting antiprogestin in human cancers," presented today at the 35th Annual San Antonio Breast Cancer Symposium.
Induction of TGF-beta by an antiprogestin in the human breast cancer cell line T-47D.
Proellex, the Company's lead compound is an antiprogestin currently being studied in a Phase 2 clinical trial for the treatment of uterine fibroids, a condition that affects approximately 13 million women in the U.
Earlier this year, the two companies announced that they had expanded their women's health collaboration to include several of Ligand's existing non-steroidal lead compound series: the antiprogestin lead series LG1447 and two progesterone agonist lead series LG2527 and LG2716.
The functioning of both the positive and the negative versions of the GeneSwitch (TM) is controlled by low doses of orally administered antiprogestin drugs.
Mifepristone is an antiprogestin licensed for pregnancy termination in more than 40 countries around the world.
Exposure of BT-474 cells to MPA in vitro also resulted in lower levels of RANKL; an effect that was independent of progesterone receptors since it occurred both in the presence and absence of the antiprogestin RU-486.
13, 2010), at 527 ("Ulipristal has similar biological effects to mifepristone, the antiprogestin used in medical abortion").