antiplasmin


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antiplasmin

 [an″te-, an″ti-plaz´min]
a substance in the blood that inhibits plasmin. The most important is α2-antiplasmin, which acts by forming stable complexes with free plasmin. It is also crosslinked to fibrin by coagulation factor XIII and inhibits the binding of plasminogen to fibrin. Inherited deficiency of α2-antiplasmin results in tendency to severe bleeding, including extravasation into joints or their synovial cavities.

an·ti·plas·min

(an'tē-plaz'min),
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin

antiplasmin

/an·ti·plas·min/ (-plaz´min) a substance in the blood that inhibits plasmin. The most important is α2-a., which forms stable complexes with free plasmin, is crosslinked to fibrin by factor XIII, and inhibits the binding of plasminogen to fibrin; deficiency results in tendency to severe bleeding, including hemarthrosis.

an·ti·plas·min

(an'tē-plaz'min)
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin.

antiplasmin

a principle in the blood that inhibits plasmin.
References in periodicals archive ?
The production of plasminogen, alpha-2 antiplasmin, histidine-rich glycoprotein and FXIII is decreased in liver diseases.
Plasmin (a fibrinolytic enzyme that breaks down blood clots) is rapidly blocked by a protein called antiplasmin.
We then performed PT; activated partial thromboplastin time (APTT); fibrinogen (clottable and immunological); d-dimer; reptilase time; thrombin times; coagulation factors II, V, VII, VIII, IX, X, XI, XII; anti-thrombin (AT); alpha-2 antiplasmin (AP); protein C (PC); mixing studies (using rabbit normal plasma); lupus anticoagulant screening and confirmatory testing (dilute Russell's viper venom [American Diagnostica, Greenwich CT], STACLOT LA, [Diagnostica-Stago, Inc.
Fibrinogen, protein S, tPA and protein C were higher in the old than the young while antiplasmin was higher in the young subjects.
12] Human genes: VWF, von Willebrand factor; LEP, leptin; MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); FBLN1, fibulin 1; FBLN2, fibulin 2; ACTS, actin, beta; CRISPLD2, Cysteine-rich secretory protein LCCL domain containing 2; SERPINF1, Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; ITM2A, Integral membrane protein 2A; LEPR, leptin receptor; ZFP36L2, zinc finger protein 36, C3H type-like 2; ELN, elastin.
Plasmin is rapidly inactivated by alpha-2 antiplasmin when not bound to fibrin therefore minimizing risk of systemic bleeding.
A study of the protection of plasmin from antiplasmin inhibition within an intact fibrin clot during the course of clot lysis.
In this study, blood samples were collected from patients to evaluate serum levels of antiplasmin, which are thought to be regulated by FAP.
Using photo-optical detection with a 405 nm halogen light source, the compact, benchtop analyzer performs many tests, including: PT, aPTT, TT, FIB (fibrinogen), factor assays, INR, ATIII, plasminogen, [alpha]-2 antiplasmin, heparin anti-Xa, protein C, APCR (activated protein C resistance), lupus screen and confirmatory, PNP, P+P, and mixing studies, as well as user-programmable tests such as clottable protein C and S.
7) discovered it as a contaminant during the purification of aZ antiplasmin, utilizing plasminogen-Sepharose affinity chromatography.
2] antiplasmin complex is involved during fibrinolytic activation and fibrinolytic therapy.