antiplasmin


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antiplasmin

 [an″te-, an″ti-plaz´min]
a substance in the blood that inhibits plasmin. The most important is α2-antiplasmin, which acts by forming stable complexes with free plasmin. It is also crosslinked to fibrin by coagulation factor XIII and inhibits the binding of plasminogen to fibrin. Inherited deficiency of α2-antiplasmin results in tendency to severe bleeding, including extravasation into joints or their synovial cavities.

an·ti·plas·min

(an'tē-plaz'min),
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin

antiplasmin

/an·ti·plas·min/ (-plaz´min) a substance in the blood that inhibits plasmin. The most important is α2-a., which forms stable complexes with free plasmin, is crosslinked to fibrin by factor XIII, and inhibits the binding of plasminogen to fibrin; deficiency results in tendency to severe bleeding, including hemarthrosis.

an·ti·plas·min

(an'tē-plaz'min)
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin.

antiplasmin

a principle in the blood that inhibits plasmin.
References in periodicals archive ?
Plasminogen, AT3, protein C and S, alpha-2 antiplasmin and alpha-1 antitrypsin are also produced in the liver.
MMP-12 has a broad range of substrates, including α-1 proteinase inhibitor, α-2 antiplasmin, plasminogen activator inhibitor-2, collagen IV, laminin, fibronectin, elastin, but not interstitial collagens.
ECE protects the cardiovascular system via promotion of fibrinolysis through antiplasmin inhibition and ACE inhibition.
Measurements included complete blood count (CBC); platelets; PT; activated partial thromboplastin time (APTT); fibrinogen (clottable, immunological); coagulation factors II, V, VII, VIII, IX, X, XI, XII; anti-thrombin (AT); alpha-2 antiplasmin (AP); Protein C (PC); mixing studies; lupus anticoagulant screening; plasminogen; thrombin-anti-thrombin; fibrin degradation products (FDP); d-dimer; and thrombin time.
Uromodulin, SERPINF1 (serpin peptidase inhibitor, clade F, [alpha]-2 antiplasmin, pigment epithelium derived factor, member 1), and CD44 were verified in an independent cohort and shown to differentiate patients with AR from other groups.
Innovative Alpha-2 Antiplasmin Diagnostic Testing Technologies and Emerging Markets
12] Human genes: VWF, von Willebrand factor; LEP, leptin; MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); FBLN1, fibulin 1; FBLN2, fibulin 2; ACTS, actin, beta; CRISPLD2, Cysteine-rich secretory protein LCCL domain containing 2; SERPINF1, Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; ITM2A, Integral membrane protein 2A; LEPR, leptin receptor; ZFP36L2, zinc finger protein 36, C3H type-like 2; ELN, elastin.
A study of the protection of plasmin from antiplasmin inhibition within an intact fibrin clot during the course of clot lysis.
Plasmin is rapidly inactivated by alpha-2 antiplasmin when not bound to fibrin therefore minimizing risk of systemic bleeding.