Screening for antiphospholipid antibodies
at diagnosis is useful.
PROMISSE showed that 20 percent of women with systemic lupus erythematosus (SLE) and/or antiphospholipid antibodies
(APL) syndrome who become pregnant are at increased risk for adverse outcomes.
Venereal Disease Research Laboratory test, tuberculosis tests, human immunodeficiency virus serology, antiphospholipid antibodies
, anti-nuclear antibodies, and anti-neutrophil cytoplasmic antibodies were negative.
2) Poor prognostic factors reported include antiphospholipid antibodies
(her IgM was positive at 29 but then normalized close to 3 months later) and hyperacute presentation.
Lupus can cause other adverse pregnancy outcomes, including transient neonatal rash, neonatal thrombocytopenia, maternal preeclampsia, and recurrent fetal loss and thrombosis associated with antiphospholipid antibodies
Antiphospholipid syndrome (APS) is associated with persistently positive antiphospholipid antibodies
(aPL), most commonly aCL and lupus-like anticoagulant (1).
Whether a woman with antiphospholipid antibodies
meets diagnostic criteria for antiphospholipid syndrome makes a huge difference in her risk of pregnancy failure.
Drug-induced lupus anticoagulants and antiphospholipid antibodies
(APAs), lupus anticoagulant, anticardiolipin antibodies (ACAs) and anti-[B.
The presence of antiphospholipid antibodies
associated with recurrent vascular thrombosis and/or pregnancy complications is characteristic for antiphospholipid syndrome.
Sneddon's syndrome (livedo reticularis and cerebrovascular lesions) with antiphospholipid antibodies
and severe dementia in a young man: a case report 1994; 89:143-146.
There are different hypothesis about thrombosis such as endothelial cell ischemia or disruption, which leads to enhancement of platelet aggregation, presence of antiphospholipid antibodies
, presence of prothrombotic factors, such as deficiencies of protein S, protein C, and antithrombin, fibrinolysis anomaly due to endothelial cell damage after the deposition of antigen-antibody and elevated von Willebrand factor antigen levels (3-6).