antiparietal cell antibody

antiparietal cell antibody

An autoantibody that occurs in megaloblastic pernicious anaemia (PA), severe atrophic gastritis, in autoimmune thyroiditis and in other autoimmune-related conditions; patients with PA may also have antithyroid antibodies. APCA is also found in 2 to 3% of the normal population and increases with age.
 
Specimen
Serum.
 
Ref range
Titre < 20 negative.
 
Method
IFA. 

antiparietal cell antibody

Immunology An autoantibody that occurs in megaloblastic–pernicious anemia–PA, severe atrophic gastritis; in autoimmune thyroiditis, Pts with PA may also have antithyroid antibodies; APCA is also found in 2 to 3% of the normal population and its presence ↑ with age