antiestrogen

(redirected from antioestrogen)
Also found in: Dictionary.

estrogen

 [es´tro-jen]
a generic term for any of the estrus-producing compounds (female sex hormones), including estradiol, estriol, and estrone. Called also estrogenic hormone. In humans, the estrogens are formed in the ovary, adrenal cortex, testis, and fetoplacental unit, and are responsible for female secondary sex characteristic development, and during the menstrual cycle, act on the female genitalia to produce an environment suitable for fertilization, implantation, and nutrition of the early embryo. Uses for estrogens include oral contraceptives, hormone replacement therapy, advanced prostate or postmenopausal breast carcinoma treatment, and osteoporosis prophylaxis.
conjugated e's a mixture of the sodium salts of the sulfate esters of estrone and equilin; therapeutic uses are similar to those of other estrogens; administered orally, intravenously, intramuscularly, or intravaginally.
esterified e's a mixture of esters of estrogenic substances, principally estrone, having therapeutic uses similar to those of other estrogens.

an·ti·es·tro·gen

(an'tē-es'trō-jen),
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as androgens and progestogens do, or by competing with estrogens at estrogen receptors at the cellular level (for example, tamoxifen).
Synonym(s): estrogen antagonist

antiestrogen

/an·ti·es·tro·gen/ (-es´tro-jen) a substance capable of inhibiting the biological effects of estrogens.antiestrogen´ic

antiestrogen

[-es′trəjən]
a hormone-based product used predominantly in cancer chemotherapy. The group of antiestrogen drugs includes tamoxifen. They are used mainly in treating estrogen-dependent tumors, such as breast cancer.

an·ti·es·tro·gen

(an'tē-es'trō-jĕn)
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues.
Synonym(s): antioestrogen.

antiestrogen

1. blocking the action of estrogens.
2. an agent that so acts.
References in periodicals archive ?
Tamoxifen has been found as an antioestrogen to significantly reduce the risk of recurrent or contralateral breast cancer.
Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antioestrogen ICI 182,780 (Faslodex).
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antioestrogen resistance in human breast cancer cells.
The influence of CYP2136, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z4-hydroxy-tamoxifen in human liver.
It is now available in the USA and Brazil for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following antioestrogen therapy such as tamoxifen.
Effects of a non-steroidal pure antioestrogen, ZM 189,154, on oestrogen target organs of the rat including bones.
Effects of a non-steroidal pure antioestrogen, ZM189,154, on oestrogen target organs of the rat including bones.
Determination of urinary lignans and phytoestrogen metabolites, potential antioestrogens and anticarcinogens, in urine of women on various habitual diets.
Clodronate improves bone mineral density in post-menopausal breast cancer patients treated with adjuvant antioestrogens.