antinuclear antibody


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

an·ti·nu·cle·ar an·ti·bod·y (ANA),

an antibody showing an affinity for nuclear antigens including DNA and found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, and in some of their healthy relatives; as well as about 1% of otherwise healthy people. Different antinuclear antibodies generate distinctive patterns on immunofluorescence staining tests. These patterns have clinical relevance and reflect which nuclear constituents (autoantigens) are generative specific antibody responses.

antinuclear antibody

n. Abbr. ANA
Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.

antinuclear antibody (ANA)

[-no̅o̅′klē·ər]
an autoantibody directed against nuclear antigens. Antinuclear antibodies are found in the blood serum of patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, polymyositis, scleroderma, Raynaud's disease, mixed connective tissue disease, and a number of nonrheumatic disorders ranging from lymphomas, leukemias, primary biliary cirrhosis, thyroiditis, chronic active hepatitis, and adverse drug reactions. The antibodies are often detected with an immunofluorescent assay technique.

antinuclear antibody

Any of a number of circulating antibodies directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein. ANAs are often present in serum of patients with SLE and other connective tissue diseases.

antinuclear antibody

ANA Immunology Any of a number of circulating antibodies that are directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein; ANAs are often present in serum of Pts with SLE and other connective tissue diseases. See Speckled pattern.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor (ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, in some of their healthy relatives, and in about 1% of unaffected people.

antinuclear antibody,

n an autoantibody that reacts with nuclear material and is present in indivi-duals with autoimmune disorders; detectable by immunoflourescent assay technique.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor(ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and some collagen diseases.

antinuclear antibody

see antinuclear antibody.
References in periodicals archive ?
The negative result in the antinuclear antibody testing argued against Sjogren syndrome, however.
a) Adjusted for age, smoking status, total years of pesticide exposure (quartiles), cholesterol, and triglycerides; one value was missing for IgA, for a total number of 136 for IgA analyses and 137 for IgG and antinuclear antibody analyses.
The two groups also differed significantly in the use of tests to measure levels of vitamin D, rheumatoid factor, antinuclear antibody, and anti--cyclic citrullinated peptide (anti-CCP) antibody.
To be eligible for enrollment in the Phase 3 trials, patients must be serologically active, with unequivocally positive antinuclear antibody (ANA) test results assessed at 2 independent time points (HEp-2 ANA > 1:80 and/or anti-dsDNA > 30 IU/mL).
Stool microscopy, ESR, antinuclear antibody, rheumatoid factor, complement components, ANCA, thyroid function tests, aspergillus antibody titer, Lyme antibody titer, and barium swallow study were normal.
The erythrocyte sedimentation rate (ESR) was 23 mm/h, and the antinuclear antibody (ANA) test was positive with a speckled pattern.
Her antinuclear antibody (ANA) screen was positive (1:320 titer), and the pattern was homogeneous.
New EliA([R]) individual Extractable Nuclear Antibody (ENA) assays allow the physician to better evaluate positive Antinuclear Antibody (ANA) screening test results
Levels also were significantly lower in patients who were antinuclear antibody positive (14.
To be eligible for enrollment in the Phase 3 trials, patients must be serologically active, with unequivocal antinuclear antibody (ANA) test results assessed at 2 independent time points (HEp-2 ANA of at least 1:80 and/or anti-dsDNA of at least 30 IU/mL).