antineutrophil cytoplasmic antibody


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to antineutrophil cytoplasmic antibody: Wegener's granulomatosis, vasculitis, antinuclear antibody, Protein electrophoresis

antineutrophil cytoplasmic antibody

an autoantibody to cytoplasmic constituents of monocytes and neutrophils found in patients with vasculitis.

antineutrophil cytoplasmic antibody

ANCA Immunology Any autoantibody directed against certain components of granulocytes, myeloid-specific lysosomal enzymes; ANCAs are most commonly found in systemic vasculitides–eg, necrotizing vasculitis, active generalized Wegener's granulomatosis–WG, 84-100% are positive, polyarteritis nodosa, inflammatory conditions of the lung and kidney–eg, crescentic glomerulonephritis, unexplained renal failure, Churg-Strauss syndrome, HIV infection, IBD, drug-induced lupus, SLE, rheumatoid arthritis, and others

an·ti·neu·tro·phil cy·to·plas·mic an·ti·bod·y

(ANCA) (an'tē-nū'trō-fil sī'tō-plaz'mik an'ti-bod-ē)
An autoantibody to cytoplasmic constituents of monocytes and neutrophils found in patients with vasculitis.

antineutrophil cytoplasmic antibody

Abbreviation: ANCA
An autoantibody found in the blood of patients with certain forms of vasculitis (such as Churg-Strauss syndrome, microscopic polyangiitis, Wegener granulomatosis) esp. when it affects small blood vessels.
See also: antibody
References in periodicals archive ?
Cytoplasmic antineutrophil cytoplasmic antibody positive pauci-immune glomerulonephritis associated with infectious endocarditis," Clinical Nephrology, vol.
Anti-thyroid drugs and antineutrophil cytoplasmic antibody positive vasculitis.
Antineutrophil cytoplasmic antibody subtypes in children and adolescents after ileal pouch-anal anastomosis for ulcerative colitis.
Rituxan is also being studied in other autoimmune diseases with significant unmet medical needs, including antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
Perinuclear antineutrophil cytoplasmic antibody, cytoplasmic antineutrophil cytoplasmic antibodies and myeloperoxidase antibody was negative.
26,27) Antineutrophil cytoplasmic antibody continues to be a valuable tool for evaluation of vasculitides, and newer studies suggest ANCA can be a useful diagnostic test in other diseases as well.
The following tests were performed in all study participants for the study purposes: anti-nuclear antibody (ANA) anti-double stranded DNA (anti- dsDNA) anti-liver/kidney microsomal type 1 (LKM-1) anti-smooth muscle antibody (Anti-SMA) antimitochondrial antibodies (AMA) perinuclear antineutrophil cytoplasmic antibody (p-ANCA) cytoplasmic ANCA (c-ANCA) anti-SSA/Ro anti- SSB/La anti-Scl-70 anti-centromere antibody Anti-Jo-1 anti-thyroid peroxidase (anti-tpo) Anti thyroglobulin (anti-Tg) Anti-U1small nuclear (sn) RNP (Anti-U1snRNP) Anti Smith antibody (Anti- Sm) and anti-cardiolipin antibodies (ACA).
Serological tests were negative for antinuclear antibody (ANA), anti-dsDNA, antineutrophil cytoplasmic antibody (ANCA), and hepatitis markers.
Results were also normal for a hypercoagulable work-up appropriate for presumed stroke in a young person: protein C, protein S, prothrombin gene mutation, Factor V Leiden, antithrombin III, antiphospholipid, homocysteine, erythrocyte sedimentation rate, C-reactive protein, antinuclear antibody, antineutrophil cytoplasmic antibody, and sicca syndrome A or B antibodies.
Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a systematic review.
Vasculitis and glomerulonephritis: a subgroup with an antineutrophil cytoplasmic antibody.