antineutrophil cytoplasmic antibody


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Related to antineutrophil cytoplasmic antibody: Wegener's granulomatosis, vasculitis, antinuclear antibody, Protein electrophoresis

antineutrophil cytoplasmic antibody

an autoantibody to cytoplasmic constituents of monocytes and neutrophils found in patients with vasculitis.

antineutrophil cytoplasmic antibody

ANCA Immunology Any autoantibody directed against certain components of granulocytes, myeloid-specific lysosomal enzymes; ANCAs are most commonly found in systemic vasculitides–eg, necrotizing vasculitis, active generalized Wegener's granulomatosis–WG, 84-100% are positive, polyarteritis nodosa, inflammatory conditions of the lung and kidney–eg, crescentic glomerulonephritis, unexplained renal failure, Churg-Strauss syndrome, HIV infection, IBD, drug-induced lupus, SLE, rheumatoid arthritis, and others

an·ti·neu·tro·phil cy·to·plas·mic an·ti·bod·y

(ANCA) (an'tē-nū'trō-fil sī'tō-plaz'mik an'ti-bod-ē)
An autoantibody to cytoplasmic constituents of monocytes and neutrophils found in patients with vasculitis.

antineutrophil cytoplasmic antibody

Abbreviation: ANCA
An autoantibody found in the blood of patients with certain forms of vasculitis (such as Churg-Strauss syndrome, microscopic polyangiitis, Wegener granulomatosis) esp. when it affects small blood vessels.
See also: antibody
References in periodicals archive ?
Influence of disease manifestation and antineutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with Wegener's granulomatosis.
Antineutrophil cytoplasmic antibody titers are not reliable indicators of disease activity.
Using antineutrophil cytoplasmic antibody testing to diagnose vasculitis: can test-ordering guidelines improve diagnostic accuracy?
Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody -associated small-vessel vasculitis.
Ideally, evaluation should include a biopsy, measurement of the antineutrophil cytoplasmic antibody (e-ANCA) level, and other laboratory evaluations to rule out sarcoidosis and autoimmune disease.
Two months later, rapidly progressive necrotizing glomerulonephritis developed together with seropositivity for perinuclear antineutrophil cytoplasmic antibody.
Normal antineutrophil cytoplasmic antibody, cytomegalovirus, and toxoplasma titers were found.
Measurements of the complete blood count, erythrocyte sedimentation rate, antineutrophil cytoplasmic antibody (ANCA) level, and antinuclear antibody (ANA) level were all within normal ranges.
Laboratory measurements of antinuclear antibody (ANA), antineutrophil cytoplasmic antibody (c-ANCA), C-reactive protein, and rheumatoid factor levels were within normal limits.