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antimycin A

   Also found in: Wikipedia 0.01 sec.
antimycin A
a respiratory inhibitor isolated from Streptomyces. Blocks electron transfer from cytochrome b to cytochrome c1.

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In malignant cells, the results demonstrated that rhIGFBP-3 enhanced apoptosis induced by ceramide, antimycin A and the UV-mimetic 4 NQO between 50-200%.
It is generally accepted that the mitochondrion is the major source of intracellular ROS, which is enhanced by electron transport inhibitors such as ischemiareperfusion, rotenone, antimycin A, and diphenyleneiodonium (46-48).
 
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