antimuscarinic agents

antimuscarinic agents

; anticholinergic agents agents that reduce symptoms of parkinsonism
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Clinical trials showed the incidence of dry mouth, and constipation also occurs less frequently in patients on Regurin(R) XL compared to all other antimuscarinic agents, and approximately 50% less than Regurin(R) 20mg twice daily(9,10).
All of the antimuscarinic agents exhibit functional selectivity for urinary bladder over secretory glands (e.
Darifenacin (Enablex) thus stands in marked contrast to traditional antimuscarinic agents, which are effective for overactive bladder but have a high rate of limiting cognitive side effects due to their broad spectrum of action.
Other pharmacologic agents that have shown some benefit in nonrandomized trials include tricyclic antidepressants, gabapentin, and antimuscarinic agents, particularly oxybutynin, in patients who have frequent spasms.
Concomitant use of SANCTURA XR([R]) with other antimuscarinic agents that produce dry mouth and constipation and other anticholinergic effects may increase the frequency and/or severity of such effects.
Both therapies are antimuscarinic agents, meaning they act on muscarinic receptors in the body associated with bladder control.
In fact, the long-term use of antimuscarinic agents has been characterized to a significant degree by lack of tolerability, and it is noteworthy that long-term use of SANCTURA has led to improved tolerability which we believe will help maintain a higher level of compliance.
An analysis of persistence rates with various antimuscarinic agents showed that the one-year persistence rates ranged from 14% to 35% (Fig.
The gold standard in treating OAB is the use of antimuscarinic agents, and while use of these agents has been shown effective to varying degrees, their lack of tolerability, related primarily to dry mouth, and their slow onset of action have resulted in relatively low compliance and regular switching among agents to find an optimal combination of efficacy and safety for individual patients.
Listening to the patient: a flexible approach to the use of antimuscarinic agents in overactive bladder syndrome.