For example, Roche is capitalising on the success of its HER2 inhibitor, Herceptin (trastuzumab), with the development of an antibody-drug conjugate, trastuzumab emtansine, which consists of the monoclonal antibody, trastuzumab, linked to the antimicrotubule agent
The vinca alkaloids and taxanes are also known as antimicrotubule agents
(Iain Brown, Jay N Sangrithi-Wallace and Andrew C Schofield)
The contents of this report are as follows: General Working Model & Methodology 3 Introduction 5 More Vascular Targeting Drugs in Clinical Trial 8 The Vanguard VTA in New Clinical Programs 10 Combination of VTAs and antiangiogenic agents 18 The Non-Combretastatins Agents that Destabilize Microtubules 21 Antimicrotubule Agents
with Vascular Targeting Potential 27 Monoclonal Antibodies as Delivery Vehicles 30 Targeting Endothelial Cell-Specific Adhesion 37 Encapsulation in cationic liposomes 40 Disclaimer 42 Liability 42 Completeness 42 Appendix 43 Various tables are also included within this report.
The technology was discovered and patented by the Pharmaceutical Research Institute of Warsaw Poland and involves compounds that appear to be novel antimicrotubule agents